Cancer and platelet crosstalk: opportunities and challenges for aspirin and other antiplatelet agents
Platelets have long been recognized as key players in hemostasis and thrombosis;
however, growing evidence suggests that they are also significantly involved in cancer, the …
however, growing evidence suggests that they are also significantly involved in cancer, the …
Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond
Platelets are small anucleate blood cells generated from megakaryocytes in the bone
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …
[HTML][HTML] Advances in haemostatic sponges: Characteristics and the underlying mechanisms for rapid haemostasis
In traumatized patients, the primary cause of mortality is uncontrollable continuous bleeding
and unexpected intraoperative bleeding which is likely to increase the risk of complications …
and unexpected intraoperative bleeding which is likely to increase the risk of complications …
Platelets and platelet adhesion molecules: novel mechanisms of thrombosis and anti-thrombotic therapies
Platelets are central mediators of thrombosis and hemostasis. At the site of vascular injury,
platelet accumulation (ie adhesion and aggregation) constitutes the first wave of hemostasis …
platelet accumulation (ie adhesion and aggregation) constitutes the first wave of hemostasis …
Pathophysiology of immune thrombocytopenia
Recent evidence of distinct ITP pathophysiology has opened new exploratory avenues for
disease management. We will discuss the utility of investigations into these mechanisms of …
disease management. We will discuss the utility of investigations into these mechanisms of …
GPIbα is required for platelet-mediated hepatic thrombopoietin generation
Thrombopoietin (TPO), a hematopoietic growth factor produced predominantly by the liver, is
essential for thrombopoiesis. Prevailing theory posits that circulating TPO levels are …
essential for thrombopoiesis. Prevailing theory posits that circulating TPO levels are …
The integrin PSI domain has an endogenous thiol isomerase function and is a novel target for antiplatelet therapy
G Zhu, Q Zhang, EC Reddy, N Carrim… - Blood, The Journal …, 2017 - ashpublications.org
Integrins are a large family of heterodimeric transmembrane receptors differentially
expressed on almost all metazoan cells. Integrin β subunits contain a highly conserved …
expressed on almost all metazoan cells. Integrin β subunits contain a highly conserved …
[HTML][HTML] Plant-based food cyanidin-3-glucoside modulates human platelet glycoprotein VI signaling and inhibits platelet activation and thrombus formation
Y Yao, Y Chen, R Adili, T McKeown, P Chen, G Zhu… - The Journal of …, 2017 - Elsevier
Background Platelets play an important role in hemostasis, thrombosis, and atherosclerosis.
Glycoprotein VI (GPVI) is a major platelet receptor that interacts with exposed collagen on …
Glycoprotein VI (GPVI) is a major platelet receptor that interacts with exposed collagen on …
Tantalum-containing mesoporous bioactive glass powder for hemostasis
This study evaluates the hemostatic properties of tantalum-containing mesoporous bioactive
glasses (Ta-MBGs) through a suite of in-vitro methods: hemolysis percentage, zeta potential …
glasses (Ta-MBGs) through a suite of in-vitro methods: hemolysis percentage, zeta potential …
The combination of danhong injection plus tissue plasminogen activator ameliorates mouse tail thrombosis-induced by κ-carrageenan
H Zhou, J Zhu, H Wan, C Shao, T Chen, J Yang, Y He… - Phytomedicine, 2022 - Elsevier
Background After thrombosis, t-PA thrombolysis is the first choice, but the use of t-PA can
easily lead to hemorrhagic injury and neurotoxicity. The combination of Danhong injection …
easily lead to hemorrhagic injury and neurotoxicity. The combination of Danhong injection …