Cancer and platelet crosstalk: opportunities and challenges for aspirin and other antiplatelet agents

XR Xu, GM Yousef, H Ni - Blood, The Journal of the American …, 2018 - ashpublications.org
Platelets have long been recognized as key players in hemostasis and thrombosis;
however, growing evidence suggests that they are also significantly involved in cancer, the …

Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond

XR Xu, D Zhang, BE Oswald, N Carrim… - Critical reviews in …, 2016 - Taylor & Francis
Platelets are small anucleate blood cells generated from megakaryocytes in the bone
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …

[HTML][HTML] Advances in haemostatic sponges: Characteristics and the underlying mechanisms for rapid haemostasis

A Nepal, HDN Tran, NT Nguyen, HT Ta - Bioactive Materials, 2023 - Elsevier
In traumatized patients, the primary cause of mortality is uncontrollable continuous bleeding
and unexpected intraoperative bleeding which is likely to increase the risk of complications …

Platelets and platelet adhesion molecules: novel mechanisms of thrombosis and anti-thrombotic therapies

XR Xu, N Carrim, MAD Neves, T McKeown… - Thrombosis journal, 2016 - Springer
Platelets are central mediators of thrombosis and hemostasis. At the site of vascular injury,
platelet accumulation (ie adhesion and aggregation) constitutes the first wave of hemostasis …

Pathophysiology of immune thrombocytopenia

J Li, JA Sullivan, H Ni - Current opinion in hematology, 2018 - journals.lww.com
Recent evidence of distinct ITP pathophysiology has opened new exploratory avenues for
disease management. We will discuss the utility of investigations into these mechanisms of …

GPIbα is required for platelet-mediated hepatic thrombopoietin generation

M Xu, J Li, MAD Neves, G Zhu, N Carrim… - Blood, The Journal …, 2018 - ashpublications.org
Thrombopoietin (TPO), a hematopoietic growth factor produced predominantly by the liver, is
essential for thrombopoiesis. Prevailing theory posits that circulating TPO levels are …

The integrin PSI domain has an endogenous thiol isomerase function and is a novel target for antiplatelet therapy

G Zhu, Q Zhang, EC Reddy, N Carrim… - Blood, The Journal …, 2017 - ashpublications.org
Integrins are a large family of heterodimeric transmembrane receptors differentially
expressed on almost all metazoan cells. Integrin β subunits contain a highly conserved …

[HTML][HTML] Plant-based food cyanidin-3-glucoside modulates human platelet glycoprotein VI signaling and inhibits platelet activation and thrombus formation

Y Yao, Y Chen, R Adili, T McKeown, P Chen, G Zhu… - The Journal of …, 2017 - Elsevier
Background Platelets play an important role in hemostasis, thrombosis, and atherosclerosis.
Glycoprotein VI (GPVI) is a major platelet receptor that interacts with exposed collagen on …

Tantalum-containing mesoporous bioactive glass powder for hemostasis

M Nagrath, R Gallant, AR Yazdi… - Journal of …, 2021 - journals.sagepub.com
This study evaluates the hemostatic properties of tantalum-containing mesoporous bioactive
glasses (Ta-MBGs) through a suite of in-vitro methods: hemolysis percentage, zeta potential …

The combination of danhong injection plus tissue plasminogen activator ameliorates mouse tail thrombosis-induced by κ-carrageenan

H Zhou, J Zhu, H Wan, C Shao, T Chen, J Yang, Y He… - Phytomedicine, 2022 - Elsevier
Background After thrombosis, t-PA thrombolysis is the first choice, but the use of t-PA can
easily lead to hemorrhagic injury and neurotoxicity. The combination of Danhong injection …