Every year, cancer claims millions of lives around the globe. Unfortunately, model systems
that accurately mimic human oncology–a requirement for the development of more effective …

Hypoxia has been shown to increase the aggressiveness and severity of tumor progression.
Along with chronic and acute hypoxic regions, solid tumors contain regions of cycling …

Hypoxia is a unique characteristic of the solid tumor microenvironment. Hypoxia contributes
to multi-drug resistance, metastasis and cancer relapse through numerous molecular …

Hypoxia is characterized as insufficient oxygen delivery to tissues and cells in the body and
is prevalent in many human physiology processes and diseases. Thus, it is an attractive …

Variations in oxygen levels play key roles in numerous physiological and pathological
processes, but are often not properly controlled in in vitro models, introducing a significant …

The heterogeneity of native tissues requires complex materials to provide suitable
substitutes for model systems and replacement tissues. Functionally graded materials have …

Cardiac organoids are 3-dimensional (3D) structures composed of tissue or niche-specific
cells, obtained from diverse sources, encapsulated in either a naturally derived or synthetic …

To understand how the microvasculature grows and remodels, researchers require
reproducible systems that emulate the function of living tissue. Innovative contributions …

Neovascularization, the formation of new blood vessels, has received much research
attention due to its implications for physiological processes and diseases. Most studies …

Microfluidic organ-on-a-chip designs are used to mimic human tissues, including the
vasculature. Here we present a novel microfluidic device that allows the interaction of …