The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

Ca2+-ATPases (pumps) are key actors in the regulation of Ca2+ in eukaryotic cells and are
thus essential to the correct functioning of the cell machinery. They have high affinity for …

The Golgi apparatus is known to underpin many important cellular homeostatic functions,
including trafficking, sorting and modifications of proteins or lipids. These functions are …

All living organisms require nutrient minerals for growth and have developed mechanisms to
acquire, utilize, and store nutrient minerals effectively. In the aqueous cellular environment …

Transition metal ions are essential nutrients to all forms of life. Iron, copper, zinc,
manganese, cobalt and nickel all have unique chemical and physical properties that make …

Intracellular Ca2+-transport ATPases exert a pivotal role in the endoplasmic reticulum and in
the compartments of the cellular secretory pathway by maintaining a sufficiently high …

The various splice variants of the three SERCA-and the two SPCA-pump genes in higher
vertebrates encode P-type ATPases of the P2A group found respectively in the membranes …

A whole range of cell functions are regulated by the free cytosolic Ca2+ concentration.
Activator Ca2+ from the extracellular space enters the cell through various types of Ca2+ …

Darier's disease is a rare cutaneous disease with an autosomal dominant mode of
inheritance. Greasy papules and plaques arise on the seborrheic areas and in the flexures …

The autosomal‐dominant genodermatoses Darier disease and Hailey‐Hailey disease
present special challenges to dermatologists. Despite their similar pathogenesis featuring …