The discovery of microRNAs and their role in diseases was a breakthrough that inspired
research into microRNAs as drug targets. Cardiovascular diseases are an area in which …

In recent years, nanoparticles have evolved to a clinical modality to deliver diverse nucleic
acids. Rising interest in nanomedicines comes from proven safety and efficacy profiles …

Owing to the prevalence and high mortality rates of cardiac diseases, a more detailed
characterization of the human heart is necessary; however, this has been largely impeded …

Human biology is tightly linked to proteins, yet most measurements do not precisely
determine alternatively spliced sequences or posttranslational modifications. Here, we …

Protein subcellular localization is tightly controlled and intimately linked to protein function in
health and disease. Capturing the spatial proteome—that is, the localizations of proteins and …

Gene expression in human tissue has primarily been studied on the transcriptional level,
largely neglecting translational regulation. Here, we analyze the translatomes of 80 human …

Identification of post-translationally or chemically modified peptides in mass spectrometry-
based proteomics experiments is a crucial yet challenging task. We have recently introduced …

Translated small open reading frames (smORFs) can have important regulatory roles and
encode microproteins, yet their genome-wide identification has been challenging. We …

Research showing that microRNAs (miRNAs) are versatile regulators of gene expression
has instigated tremendous interest in cardiovascular research. The overwhelming majority of …

Cardiac fibrosis is a pathological condition that occurs after injury and during aging.
Currently, there are limited means to effectively reduce or reverse fibrosis. Key to identifying …