Tumor necrosis factor (TNF)‐related apoptosis‐inducing ligand (TRAIL) is a member of the
TNF superfamily that can lead to the induction of apoptosis in tumor or infected cells …

Simple Summary Breast cancer remains the most common malignancy in women. In this
review, we explore the role of the CXCL12/CXCR4 pathway in breast cancer. We show that …

Evasion from apoptosis is an important hallmark of cancer cells. Alterations of apoptosis
pathways are especially critical as they confer resistance to conventional anti-cancer …

One of the classic hallmarks of cancer is disruption of cell death signalling. Inhibition of cell
death promotes tumour growth and metastasis, causes resistance to chemo‐and …

Since their identification more than 20 years ago, the death receptors CD 95, TRAILR 1, and
TRAILR 2 have been intensively studied with respect to their cell death‐inducing activities …

Death ligands such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL;
TNFSF10) and their corresponding death receptors (eg, DR5) not only initiate apoptosis …

TRAIL induces selective tumor cell death through TRAIL-R1 and TRAIL-R2. Despite the fact
that these receptors share high structural homologies, induction of apoptosis upon ER …

The tumor necrosis factor (TNF) superfamily member TNF-related apoptosis-inducing ligand
(TRAIL) induces apoptosis in cancer cells via death receptor (DR) activation with little toxicity …

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising anticancer
agent for esophageal squamous cell carcinoma (ESCC). Forced expression of CHOP, one …

The continuing efforts to exploit the death receptor agonists, such as the tumour necrosis
factor (TNF)-related apoptosis-inducing ligand (TRAIL), for cancer therapy, have largely …