AGC kinases, mechanisms of regulation and innovative drug development
The group of AGC kinases consists of 63 evolutionarily related serine/threonine protein
kinases comprising PDK1, PKB/Akt, SGK, PKC, PRK/PKN, MSK, RSK, S6K, PKA, PKG …
kinases comprising PDK1, PKB/Akt, SGK, PKC, PRK/PKN, MSK, RSK, S6K, PKA, PKG …
[HTML][HTML] Biochemical methods for monitoring protein thiol redox states in biological systems
Oxidative post-translational modifications of proteins resulting from events that increase
cellular oxidant levels play important roles in physiological and pathophysiological …
cellular oxidant levels play important roles in physiological and pathophysiological …
Blood pressure–lowering by the antioxidant resveratrol is counterintuitively mediated by oxidation of cGMP-dependent protein kinase
Background: The health-promoting and disease-limiting abilities of resveratrol, a natural
polyphenol, has led to considerable interest in understanding the mechanisms of its …
polyphenol, has led to considerable interest in understanding the mechanisms of its …
Protein kinase G Iα oxidation paradoxically underlies blood pressure lowering by the reductant hydrogen sulfide
D Stubbert, O Prysyazhna, O Rudyk, J Scotcher… - …, 2014 - Am Heart Assoc
Dysregulated blood pressure control leading to hypertension is prevalent and is a risk factor
for several common diseases. Fully understanding blood pressure regulation offers the …
for several common diseases. Fully understanding blood pressure regulation offers the …
Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase
RL Charles, O Rudyk, O Prysyazhna… - Proceedings of the …, 2014 - National Acad Sciences
Soluble epoxide hydrolase (sEH) is inhibited by electrophilic lipids by their adduction to
Cys521 proximal to its catalytic center. This inhibition prevents hydrolysis of the enzymes' …
Cys521 proximal to its catalytic center. This inhibition prevents hydrolysis of the enzymes' …
Nitrite and myocardial ischaemia reperfusion injury. Where are we now?
Cardiovascular disease remains the leading cause of death worldwide despite major
advances in technology and treatment, with coronary heart disease (CHD) being a key …
advances in technology and treatment, with coronary heart disease (CHD) being a key …
Old dog, new tricks: novel cardiac targets and stress regulation by protein kinase G
The second messenger cyclic guanosine 3′ 5′ monophosphate (cGMP) and its
downstream effector protein kinase G (PKG) have been discovered more than 40 years ago …
downstream effector protein kinase G (PKG) have been discovered more than 40 years ago …
Pharmacological manipulation of cGMP and NO/cGMP in CNS drug discovery
The development of small molecule modulators of NO/cGMP signaling for use in the CNS
has lagged far behind the use of such clinical agents in the periphery, despite the central …
has lagged far behind the use of such clinical agents in the periphery, despite the central …
Subcellular localization of oxidants and redox modulation of endothelial nitric oxide synthase
2498 MARON BA et al. tion of eNOS is dynamically regulated9 and the enzyme is thus
exposed to different concentrations of ROS depending upon where in the cell the protein is …
exposed to different concentrations of ROS depending upon where in the cell the protein is …
Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response
J Scotcher, O Prysyazhna, A Boguslavskyi… - Nature …, 2016 - nature.com
Abstract The Frank–Starling mechanism allows the amount of blood entering the heart from
the veins to be precisely matched with the amount pumped out to the arterial circulation. As …
the veins to be precisely matched with the amount pumped out to the arterial circulation. As …