DNA binding and Topoisomerase inhibition: How can these mechanisms be explored to design more specific anticancer agents?

SMV de Almeida, AG Ribeiro, GC de Lima Silva… - Biomedicine & …, 2017 - Elsevier
DNA is considered one of the most promising targets of molecules with anticancer activity
potential. Its key role in various cell division mechanisms, which commands the intense …

[图书][B] Antimalarial natural products

DGI Kingston, MB Cassera - 2022 - Springer
Natural products have made a crucial and unique contribution to human health, and this is
especially true in the case of malaria, where the natural products quinine and artemisinin …

Synthesis, DNA interaction, topoisomerase I, II inhibitory and cytotoxic effects of water soluble silicon (IV) phthalocyanine and napthalocyanines bearing 1 …

H Baş, B Barut, Z Biyiklioglu, A Özel - Dyes and Pigments, 2019 - Elsevier
In this study, axially 1-acetylpiperazine substituted silicon (IV) phthalocyanine,
naphthalocyanine 2, 3 and their water soluble derivatives 2a, 3a were synthesized for the …

Highly efficient and facile fabrication of monodispersed Au nanoparticles using pullulan and their application as anticancer drug carriers

S Laksee, S Puthong, T Teerawatananond… - Carbohydrate …, 2017 - Elsevier
This work presented a simple, rapid, green and efficient approach to the synthesis of gold
nanoparticles using pullulan as a reducing/stabilizing/capping agent for drug delivery …

Cyclopropenium Sulfide as Lewis Base Catalyst for Chemoselective and Regioselective Electrophilic Selenylation of Phenols

R Chen, T Zheng, X Jiang, YY Yeung - ACS Catalysis, 2024 - ACS Publications
Soft Lewis basic sulfides are frequently employed as catalysts in the electrophilic
functionalization of unsaturated compounds because the reactions can be operated under …

Synthesis of natural product-like polyheterocycles via one-pot cascade oximation, C–H activation, and alkyne annulation

L Zheng, Y Bin, Y Wang, R Hua - The Journal of Organic …, 2016 - ACS Publications
An efficient protocol for the direct transformation of chroman-4-ones to tricyclic fused
pyridines with the skeleton of cassiarins, a family of alkaloids with antimalarial activity, was …

Synthesis, characterization and DNA interaction properties of the novel peripherally tetra 4-(3-methyl-4-(3-morpholinopropyl)-5-oxo-4, 5-dihydro-1H-1, 2, 4-triazol-1-yl) …

Ü Demirbaş, B Barut, A Özel, F Çelik, H Kantekin… - Journal of Molecular …, 2019 - Elsevier
Abstract The triazol compound 3-methyl-4-(3-morpholinopropyl)-1H-1, 2, 4-triazol-5 (4H)-
one (3), phthalonitrile compound 4-(3-methyl-4-(3-morpholinopropyl)-5-oxo-4, 5-dihydro-1H …

A rhodium-catalyzed C–H activation/cyclization approach toward the total syntheses of cassiarin C and 8-O-methylcassiarin A from a common intermediate

DF Vargas, S Fonzo, SO Simonetti… - Organic & …, 2024 - pubs.rsc.org
Three short and efficient total syntheses of cassiarin C are reported, from a chromanone
common key intermediate. AC–H activation strategy, under rhodium catalysis on its pivaloyl …

Synthesis of 1-substituted isoquinolines by heterocyclization of TosMIC derivatives: total synthesis of cassiarin A

S Gutierrez, A Coppola, D Sucunza, C Burgos… - Organic …, 2016 - ACS Publications
A new method for the synthesis of 1-substituted isoquinolines by a heterocyclization that
involves α-benzyl TosMIC derivatives and different electrophiles has been developed. This …

Chalcogenation/pyrrolo (pyrido) annulation of 2-(3-butenyl) quinazolin-4 (3H)-ones by arylsulfenyl (selenyl) chlorides

AI Vaskevych, NO Savinchuk, RI Vaskevych… - Tetrahedron, 2022 - Elsevier
Abstract Arylsulfenyl chlorides react with 2-(3-butenyl) quinazolinones in dichloromethane
by the Ad E addition mechanism to give 2-(3-arylthio-4-chlorobutyl) quinazolin-4 (3Н)-ones …