DNA binding and Topoisomerase inhibition: How can these mechanisms be explored to design more specific anticancer agents?
SMV de Almeida, AG Ribeiro, GC de Lima Silva… - Biomedicine & …, 2017 - Elsevier
DNA is considered one of the most promising targets of molecules with anticancer activity
potential. Its key role in various cell division mechanisms, which commands the intense …
potential. Its key role in various cell division mechanisms, which commands the intense …
[图书][B] Antimalarial natural products
DGI Kingston, MB Cassera - 2022 - Springer
Natural products have made a crucial and unique contribution to human health, and this is
especially true in the case of malaria, where the natural products quinine and artemisinin …
especially true in the case of malaria, where the natural products quinine and artemisinin …
Synthesis, DNA interaction, topoisomerase I, II inhibitory and cytotoxic effects of water soluble silicon (IV) phthalocyanine and napthalocyanines bearing 1 …
In this study, axially 1-acetylpiperazine substituted silicon (IV) phthalocyanine,
naphthalocyanine 2, 3 and their water soluble derivatives 2a, 3a were synthesized for the …
naphthalocyanine 2, 3 and their water soluble derivatives 2a, 3a were synthesized for the …
Highly efficient and facile fabrication of monodispersed Au nanoparticles using pullulan and their application as anticancer drug carriers
S Laksee, S Puthong, T Teerawatananond… - Carbohydrate …, 2017 - Elsevier
This work presented a simple, rapid, green and efficient approach to the synthesis of gold
nanoparticles using pullulan as a reducing/stabilizing/capping agent for drug delivery …
nanoparticles using pullulan as a reducing/stabilizing/capping agent for drug delivery …
Cyclopropenium Sulfide as Lewis Base Catalyst for Chemoselective and Regioselective Electrophilic Selenylation of Phenols
Soft Lewis basic sulfides are frequently employed as catalysts in the electrophilic
functionalization of unsaturated compounds because the reactions can be operated under …
functionalization of unsaturated compounds because the reactions can be operated under …
Synthesis of natural product-like polyheterocycles via one-pot cascade oximation, C–H activation, and alkyne annulation
L Zheng, Y Bin, Y Wang, R Hua - The Journal of Organic …, 2016 - ACS Publications
An efficient protocol for the direct transformation of chroman-4-ones to tricyclic fused
pyridines with the skeleton of cassiarins, a family of alkaloids with antimalarial activity, was …
pyridines with the skeleton of cassiarins, a family of alkaloids with antimalarial activity, was …
Synthesis, characterization and DNA interaction properties of the novel peripherally tetra 4-(3-methyl-4-(3-morpholinopropyl)-5-oxo-4, 5-dihydro-1H-1, 2, 4-triazol-1-yl) …
Abstract The triazol compound 3-methyl-4-(3-morpholinopropyl)-1H-1, 2, 4-triazol-5 (4H)-
one (3), phthalonitrile compound 4-(3-methyl-4-(3-morpholinopropyl)-5-oxo-4, 5-dihydro-1H …
one (3), phthalonitrile compound 4-(3-methyl-4-(3-morpholinopropyl)-5-oxo-4, 5-dihydro-1H …
A rhodium-catalyzed C–H activation/cyclization approach toward the total syntheses of cassiarin C and 8-O-methylcassiarin A from a common intermediate
DF Vargas, S Fonzo, SO Simonetti… - Organic & …, 2024 - pubs.rsc.org
Three short and efficient total syntheses of cassiarin C are reported, from a chromanone
common key intermediate. AC–H activation strategy, under rhodium catalysis on its pivaloyl …
common key intermediate. AC–H activation strategy, under rhodium catalysis on its pivaloyl …
Synthesis of 1-substituted isoquinolines by heterocyclization of TosMIC derivatives: total synthesis of cassiarin A
S Gutierrez, A Coppola, D Sucunza, C Burgos… - Organic …, 2016 - ACS Publications
A new method for the synthesis of 1-substituted isoquinolines by a heterocyclization that
involves α-benzyl TosMIC derivatives and different electrophiles has been developed. This …
involves α-benzyl TosMIC derivatives and different electrophiles has been developed. This …
Chalcogenation/pyrrolo (pyrido) annulation of 2-(3-butenyl) quinazolin-4 (3H)-ones by arylsulfenyl (selenyl) chlorides
AI Vaskevych, NO Savinchuk, RI Vaskevych… - Tetrahedron, 2022 - Elsevier
Abstract Arylsulfenyl chlorides react with 2-(3-butenyl) quinazolinones in dichloromethane
by the Ad E addition mechanism to give 2-(3-arylthio-4-chlorobutyl) quinazolin-4 (3Н)-ones …
by the Ad E addition mechanism to give 2-(3-arylthio-4-chlorobutyl) quinazolin-4 (3Н)-ones …