The intervertebral disc (IVD) is the largest avascular organ of the body. It is composed of
three parts: the nucleus pulposus (NP), the annulus fibrosus (AF) and the cartilaginous …

The degradation of cartilage in the human body is impacted by aging, disease, genetic
predisposition and continued insults resulting from daily activity. The burden of cartilage …

The extent of ageing in the musculoskeletal system during the life course affects the quality
and length of life. Loss of bone, degraded articular cartilage, and degenerate, narrowed …

Abstract Background Context Chronic inflammation is an important component of
intervertebral disc (IVD) degeneration, but there is limited knowledge about the identity and …

Intervertebral disc degeneration (IVDD) is rising worldwide and leading to significant health
issues and financial strain for patients. Traditional treatments for IVDD can alleviate pain but …

Background Intervertebral disc degeneration has an annual worldwide socioeconomic
impact masked as low back pain of over 70 billion euros. This disease has a high …

Microvasculature is essential for the exchange of gas and nutrient for most tissues in our
body. Some tissue structures such as the meniscus presents spatially confined blood …

Intervertebral discs (IVDs) are often referred to as the largest avascular structures of the
human body, yet a collective resource characterizing the vascularization of the IVD does not …

Intervertebral disc degeneration (IDD) is a common degenerative disease of the
musculoskeletal system that develops with age. It is regarded as the main cause of chronic …

Chronic low back pain is the number one cause of years lived with disability. In about 40% of
patients, chronic lower back pain is related to intervertebral disc (IVD) degeneration. The …