Disorders of consciousness after severe brain injury: therapeutic options

C Schnakers, MM Monti - Current opinion in neurology, 2017 - journals.lww.com
The growing understanding of the biology of disorders of consciousness has led to a
renaissance in the development of therapeutic interventions for patients with disorders of …

Electromagnetic brain stimulation in patients with disorders of consciousness

P Bourdillon, B Hermann, JD Sitt… - Frontiers in …, 2019 - frontiersin.org
Severe brain injury is a common cause of coma. In some cases, despite vigilance
improvement, disorders of consciousness (DoC) persist. Several states of impaired …

Minimally conscious state “plus”: diagnostic criteria and relation to functional recovery

A Thibaut, YG Bodien, S Laureys, JT Giacino - Journal of neurology, 2020 - Springer
Background We investigated the relationship between three language-dependent behaviors
(ie, command-following, intelligible verbalization, and intentional communication) and the …

Predicting outcome of patients with prolonged disorders of consciousness using machine learning models based on medical complexity

P Liuzzi, A Magliacano, F De Bellis, A Mannini… - Scientific Reports, 2022 - nature.com
Patients with severe acquired brain injury and prolonged disorders of consciousness
(pDoC) are characterized by high clinical complexity and high risk to develop medical …

Mechanisms underlying disorders of consciousness: bridging gaps to move toward an integrated translational science

AI Luppi, J Cain, LRB Spindler, UJ Górska, D Toker… - Neurocritical care, 2021 - Springer
Aim In order to successfully detect, classify, prognosticate, and develop targeted therapies
for patients with disorders of consciousness (DOC), it is crucial to improve our mechanistic …

Whole-brain modelling identifies distinct but convergent paths to unconsciousness in anaesthesia and disorders of consciousness

AI Luppi, PAM Mediano, FE Rosas, J Allanson… - Communications …, 2022 - nature.com
The human brain entertains rich spatiotemporal dynamics, which are drastically
reconfigured when consciousness is lost due to anaesthesia or disorders of consciousness …

Disorders of consciousness associated with COVID-19: a prospective multimodal study of recovery and brain connectivity

D Fischer, SB Snider, ME Barra, WR Sanders… - Neurology, 2022 - AAN Enterprises
Background and Objectives In patients with severe coronavirus disease 2019 (COVID-19),
disorders of consciousness (DoC) have emerged as a serious complication. The prognosis …

Behavioral recovery and early decision making in patients with prolonged disturbance in consciousness after traumatic brain injury

JT Giacino, M Sherer, A Christoforou… - Journal of …, 2020 - liebertpub.com
The extent of behavioral recovery that occurs in patients with traumatic disorders of
consciousness (DoC) following discharge from the acute care setting has been under …

Computational modelling in disorders of consciousness: Closing the gap towards personalised models for restoring consciousness

AI Luppi, J Cabral, R Cofre, PAM Mediano, FE Rosas… - NeuroImage, 2023 - Elsevier
Disorders of consciousness are complex conditions characterised by persistent loss of
responsiveness due to brain injury. They present diagnostic challenges and limited options …

Genetic algorithms for feature selection when classifying severe chronic disorders of consciousness

B Wutzl, K Leibnitz, F Rattay, M Kronbichler, M Murata… - PloS one, 2019 - journals.plos.org
The diagnosis and prognosis of patients with severe chronic disorders of consciousness are
still challenging issues and a high rate of misdiagnosis is evident. Hence, new tools are …