The duplication of an entire genome is no small affair. Whole genome duplication (WGD) is
a dramatic mutation with long-lasting effects, yet it occurs repeatedly in all eukaryotic …

The accurate segregation of chromosomes is essential for the survival of organisms and
cells. Mistakes can lead to aneuploidy, tumorigenesis and congenital birth defects. The …

Labeling and tracing of specific sequences in living cells has been a major challenge in
studying the spatiotemporal dynamics of native chromatin. Here we repurposed the …

Chromatin exhibits increased mobility on DNA damage, but the biophysical basis for this
behavior remains unknown. To explore the mechanisms that drive DNA damage–induced …

The centromere serves as the binding site for the kinetochore and is essential for the faithful
segregation of chromosomes throughout cell division. The point centromere in yeast is …

The centromere is essential for the segregation of chromosomes, as it serves as attachment
site for microtubules to mediate chromosome segregation during mitosis and meiosis. In …

The centromere is the genetic locus that specifies the site of kinetochore assembly, where
the chromosome will attach to the kinetochore microtubule. The pericentromere is the …

Single-particle tracking has been applied to study chromatin motion in live cells, revealing a
wealth of dynamical behavior of the genomic material once believed to be relatively static …

A growing list of diverse biological systems and their equally diverse functionalities provides
realizations of a paradigm of emergent behavior. In each of these biological systems …

Accurate genome segregation in mitosis requires that all chromosomes are bioriented on
the spindle. Cells monitor biorientation by sensing tension across sister centromeres …