In cancer patients, dendritic cells (DCs) in tumor-draining lymph nodes can present antigens
to naive T cells in ways that break immunological tolerance. The clonally expanded progeny …

Lymph nodes are secondary lymphoid organs in which immune responses of the adaptive
immune system are initiated and regulated. Distributed throughout the body and embedded …

Regulatory T cells (Tregs) are present in lymphoid and nonlymphoid tissues where they
restrict immune activation, prevent autoimmunity, and regulate inflammation. Tregs in …

In recent decades there has been a large focus on understanding the mechanisms of
peripheral immune cell infiltration into the central nervous system (CNS) in …

Abstract Background: Human lymph node (HuLN) models have emerged with invaluable
potential for immunological research and therapeutic application given their fundamental …

Traumatic brain injury (TBI) is a major cause of disability and mortality worldwide,
particularly among the elderly, yet our mechanistic understanding of what renders the post …

Vaccinia virus is the most successful vaccine in human history and functions as a protective
vaccine against smallpox and monkeypox, highlighting the importance of ongoing research …

Conventionally, immune responses are studied in the context of inflamed tissues and their
corresponding draining lymph nodes (LNs). However, little is known about the effects of …

Colorectal cancer (CRC) is the third most common type of cancer worldwide, with around 2
million new cases yearly, and the second most common cause of overall cancer mor-tality. A …

Dendritic cells (DCs) play a central role in initiating and shaping the adaptive immune
response, thanks to their ability to uptake antigens and present them to T cells. Once in the …