Emerging roles of p53 and other tumour-suppressor genes in immune regulation

C Muñoz-Fontela, A Mandinova, SA Aaronson… - Nature Reviews …, 2016 - nature.com
Tumour-suppressor genes are indispensable for the maintenance of genomic integrity.
Recently, several of these genes, including those encoding p53, PTEN, RB1 and ARF, have …

The emerging role of alternative splicing in senescence and aging

M Deschenes, B Chabot - Aging cell, 2017 - Wiley Online Library
Deregulation of precursor mRNA splicing is associated with many illnesses and has been
linked to age‐related chronic diseases. Here we review recent progress documenting how …

[HTML][HTML] CXCR4-guided liposomes regulating hypoxic and immunosuppressive microenvironment for sorafenib-resistant tumor treatment

Y Wang, Z Wang, F Jia, Q Xu, Z Shu, J Deng, A Li… - Bioactive Materials, 2022 - Elsevier
Clinical sorafenib treatment could activate CXC receptor type 4 (CXCR4)/stromal source
factor-1α (SDF-1α) axis to aggravate intra-tumoral hypoxia of hepatocellular carcinoma …

Nitrosative stress, hypernitrosylation, and autoimmune responses to nitrosylated proteins: new pathways in neuroprogressive disorders including depression and …

G Morris, M Berk, H Klein, K Walder, P Galecki… - Molecular …, 2017 - Springer
Nitric oxide plays an indispensable role in modulating cellular signaling and redox
pathways. This role is mainly effected by the readily reversible nitrosylation of selective …

Reconstructing the molecular life history of gliomas

FP Barthel, P Wesseling, RGW Verhaak - Acta neuropathologica, 2018 - Springer
At the time of their clinical manifestation, the heterogeneous group of adult and pediatric
gliomas carries a wide range of diverse somatic genomic alterations, ranging from somatic …

Liver and steroid hormones—can a touch of p53 make a difference?

M Charni-Natan, R Aloni-Grinstein, E Osher… - Frontiers in …, 2019 - frontiersin.org
The liver is the main metabolic organ in the body, serving as a significant hormonal
secretory gland and functioning to maintain hormone balance and homeostasis. Steroid …

p53's extended reach: The mutant p53 secretome

E Pavlakis, T Stiewe - Biomolecules, 2020 - mdpi.com
p53 suppresses tumorigenesis by activating a plethora of effector pathways. While most of
these operate primarily inside of cells to limit proliferation and survival of incipient cancer …

P53-regulated miR-320a targets PDL1 and is downregulated in malignant mesothelioma

C Costa, P Indovina, E Mattioli, IM Forte… - Cell Death & …, 2020 - nature.com
Malignant pleural mesothelioma (MPM) is an aggressive cancer, related to asbestos
exposure, which has a dismal prognosis. MPM diagnosis is late and often challenging …

Extracellular vesicles and PD-L1 suppress macrophages, inducing therapy resistance in TP53-deficient B-cell malignancies

E Izquierdo, D Vorholt, S Blakemore… - Blood, The Journal …, 2022 - ashpublications.org
Genetic alterations in the DNA damage response (DDR) pathway are a frequent mechanism
of resistance to chemoimmunotherapy (CIT) in B-cell malignancies. We have previously …

TP53 missense mutation is associated with increased tumor-infiltrating T cells in primary prostate cancer

HB Kaur, J Lu, LB Guedes, L Maldonado, L Reitz… - Human pathology, 2019 - Elsevier
The makeup of the tumor immune microenvironment may be associated with tumor somatic
genomic alterations and plays a key role in tumor progression and response to …