Proliferating cell nuclear antigen (PCNA) lies at the center of the faithful duplication of
eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was …

The p21CDKN1A protein is an important player in the maintenance of genome stability
through its function as a cyclin-dependent kinase inhibitor, leading to cell-cycle arrest after …

In transcription-coupled nucleotide excision repair (TC-NER), stalled RNA polymerase II
(RNA Pol II) binds CSB and CRL4 CSA, which cooperate with UVSSA and ELOF1 to recruit …

Abstract Background Ubiquitin E3 ligase CUL4A plays important oncogenic roles in the
development of cancers. DTL, one of the CUL4-DDB1 associated factors (DCAFs), may …

Base excision repair (BER) is an essential DNA repair pathway involved in the maintenance
of genome stability and thus in the prevention of human diseases, such as premature aging …

DNA replication and repair are essential cellular processes that ensure genome duplication
and safeguard the genome from deleterious mutations. Both processes utilize an …

Cytosine methylation at CpG dinucleotides is a central component of epigenetic regulation
in vertebrates, and the base excision repair (BER) pathway is important for maintaining both …

Defects in DNA replication, DNA damage response, and DNA repair compromise genomic
stability and promote cancer development. In particular, unrepaired DNA lesions can arrest …

Abstract Thymine DNA Glycosylase (TDG) is a base excision repair enzyme functioning in
DNA repair and epigenetic regulation. TDG removes thymine from mutagenic G· T mispairs …

Timely ubiquitin-mediated protein degradation is fundamental to cell cycle control, but the
precise degradation order at each cell cycle phase transition is still unclear. We investigated …