[HTML][HTML] Discovery and resupply of pharmacologically active plant-derived natural products: A review
AG Atanasov, B Waltenberger… - Biotechnology …, 2015 - Elsevier
Medicinal plants have historically proven their value as a source of molecules with
therapeutic potential, and nowadays still represent an important pool for the identification of …
therapeutic potential, and nowadays still represent an important pool for the identification of …
Natural products for human health: an historical overview of the drug discovery approaches
S Bernardini, A Tiezzi, V Laghezza Masci… - Natural product …, 2018 - Taylor & Francis
Natural products (NPs) are secondary metabolites produced and used by organisms for
defending or adapting purposes. These molecules were naturally selected during thousands …
defending or adapting purposes. These molecules were naturally selected during thousands …
[HTML][HTML] Unraveling plant natural chemical diversity for drug discovery purposes
E Lautié, O Russo, P Ducrot, JA Boutin - Frontiers in pharmacology, 2020 - frontiersin.org
The screening and testing of extracts against a variety of pharmacological targets in order to
benefit from the immense natural chemical diversity is a concern in many laboratories …
benefit from the immense natural chemical diversity is a concern in many laboratories …
Modern natural products drug discovery and its relevance to biodiversity conservation
DGI Kingston - Journal of natural products, 2011 - ACS Publications
Natural products continue to provide a diverse and unique source of bioactive lead
compounds for drug discovery, but maintaining their continued eminence as source …
compounds for drug discovery, but maintaining their continued eminence as source …
The role of natural product chemistry in drug discovery
MS Butler - Journal of natural products, 2004 - ACS Publications
Although traditionally natural products have played an important role in drug discovery, in
the past few years most Big Pharma companies have either terminated or considerably …
the past few years most Big Pharma companies have either terminated or considerably …
[HTML][HTML] Creating and screening natural product libraries
BAP Wilson, CC Thornburg, CJ Henrich… - Natural product …, 2020 - pubs.rsc.org
Covering: up to 2020 The National Cancer Institute of the United States (NCI) has initiated a
Cancer Moonshot program entitled the NCI Program for Natural Product Discovery. As part …
Cancer Moonshot program entitled the NCI Program for Natural Product Discovery. As part …
The potential of alkaloids in drug discovery
GA Cordell, ML Quinn‐Beattie… - … Journal Devoted to …, 2001 - Wiley Online Library
Alkaloids are an important group of diversely distributed, chemically, biologically and
commercially significant natural products. This article suggests why now, with the presently …
commercially significant natural products. This article suggests why now, with the presently …
The historical delivery of antibiotics from microbial natural products—can history repeat?
F Pelaez - Biochemical pharmacology, 2006 - Elsevier
Microbial natural products are the origin of most of the antibiotics on the market today.
However, research in antibiotics and natural products has declined significantly during the …
However, research in antibiotics and natural products has declined significantly during the …
Metabolomics for bioactivity assessment of natural products
ND Yuliana, A Khatib, YH Choi… - Phytotherapy …, 2011 - Wiley Online Library
Natural products historically have been a rich source of lead molecules in drug discovery,
based on their capability to create unique and diverse chemical structures. However, it is …
based on their capability to create unique and diverse chemical structures. However, it is …
Drug-like properties: guiding principles for the design of natural product libraries
D Camp, RA Davis, M Campitelli, J Ebdon… - Journal of natural …, 2012 - ACS Publications
While natural products or their derivatives and mimics have contributed around 50% of
current drugs, there has been no approach allowing front-loading of chemical space …
current drugs, there has been no approach allowing front-loading of chemical space …