Improving the ischemia-reperfusion injury in vascularized composite allotransplantation: Clinical experience and experimental implications

J He, UZ Khan, L Qing, P Wu, J Tang - Frontiers in Immunology, 2022 - frontiersin.org
Long-time ischemia worsening transplant outcomes in vascularized composite
allotransplantation (VCA) is often neglected. Ischemia-reperfusion injury (IRI) is an …

[HTML][HTML] Tolerance induction in vascularized composite allotransplantation—a brief review of preclinical models

L Huelsboemer, M Kauke-Navarro… - Transplant …, 2023 - frontierspartnerships.org
Pre-clinical studies are an obligatory tool to develop and translate novel therapeutic
strategies into clinical practice. Acute and chronic rejection mediated by the recipient's …

Biomaterials-based immunomodulation enhances survival of murine vascularized composite allografts

SD Sommerfeld, X Zhou, JC Mejías, BC Oh… - Biomaterials …, 2023 - pubs.rsc.org
Vascularized composite allotransplantation (VCA) is a restorative option for patients
suffering from severe tissue defects not amenable to conventional reconstruction. However …

Challenges and opportunities in vascularized composite allotransplantation of joints: a systematic literature review

L Zhang, IA Hoyos, C Zubler, R Rieben… - Frontiers in …, 2023 - frontiersin.org
Background Joint allotransplantation (JA) within the field of vascularized composite
allotransplantation (VCA) holds great potential for functional and non-prosthetic …

Clinical and preclinical tolerance protocols for vascularized composite allograft transplantation

JH Yang, AC Johnson, S Colakoglu… - Archives of plastic …, 2021 - thieme-connect.com
The field of vascularized composite allografts (VCAs) has undergone significant
advancement in recent decades, and VCAs are increasingly common and accepted in the …

Large animal models of vascularized composite allotransplantation: a review of immune strategies to improve allograft outcomes

AJ Matar, RL Crepeau, GS Mundinger… - Frontiers in …, 2021 - frontiersin.org
Over the past twenty years, significant technical strides have been made in the area of
vascularized composite tissue allotransplantation (VCA). As in solid organ transplantation …

Unraveling the crucial roles of FoxP3+ regulatory T cells in vascularized composite allograft tolerance induction and maintenance

MR Anggelia, HY Cheng, WY Chuang, YH Hsieh… - …, 2021 - journals.lww.com
Background. The role of regulatory T cells (Treg) in tolerance induction of vascularized
composite allotransplantation (VCA) remains unclear. This study was designed to examine …

Costimulation blockade in vascularized composite allotransplantation

D Giannis, D Moris, LC Cendales - Frontiers in immunology, 2020 - frontiersin.org
Vascular composite allotransplantation (VCA) is a field under research and has emerged as
an alternative option for the repair of severe disfiguring defects that result from infections or …

Immunogenicity and tolerance induction in vascularized composite allotransplantation

J Sun, A Adil, F Biniazan, S Haykal - Frontiers in Transplantation, 2024 - frontiersin.org
Vascularized composite allotransplantation (VCA) is the transplantation of multiple tissues
such as skin, muscle, bone, nerve, and vessels, as a functional unit (ie, hand or face) to …

The positive impact of donor bone marrow cells transplantation into immunoprivileged compartments on the survival of vascularized skin allografts

A Jundziłł, A Klimczak, E Sonmez, G Brzezicki… - Archivum Immunologiae …, 2021 - Springer
Using the vascularized skin allograft (VSA) model, we compared the tolerogenic effects of
different allogeneic bone marrow transplantation (BMT) delivery routes into …