Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies
Dementia is increasingly being recognized in cases of Parkinson's disease (PD); such cases
are termed PD dementia (PDD). The spread of fibrillar α-synuclein (α-syn) pathology from …
are termed PD dementia (PDD). The spread of fibrillar α-synuclein (α-syn) pathology from …
Nonmotor features of Parkinson's disease subtypes
C Marras, KR Chaudhuri - Movement Disorders, 2016 - Wiley Online Library
Parkinson's disease is highly heterogeneous in early clinical features and later outcomes.
This makes classifying subgroups of PD relevant to clinical research and practice …
This makes classifying subgroups of PD relevant to clinical research and practice …
Premotor and nonmotor features of Parkinson's disease
JG Goldman, R Postuma - Current opinion in neurology, 2014 - journals.lww.com
Premotor and nonmotor features of Parkinson's disease : Current Opinion in Neurology
Premotor and nonmotor features of Parkinson's disease : Current Opinion in Neurology Log in or …
Premotor and nonmotor features of Parkinson's disease : Current Opinion in Neurology Log in or …
Association of cerebrospinal fluid β-amyloid 1-42, T-tau, P-tau181, and α-synuclein levels with clinical features of drug-naive patients with early Parkinson disease
Importance We observed a significant correlation between cerebrospinal fluid (CSF) levels
of tau proteins and α-synuclein, but not β-amyloid 1-42 (Aβ1-42), and lower concentration of …
of tau proteins and α-synuclein, but not β-amyloid 1-42 (Aβ1-42), and lower concentration of …
Cerebrospinal fluid biomarkers in Parkinson disease
L Parnetti, A Castrioto, D Chiasserini… - Nature Reviews …, 2013 - nature.com
Clinical diagnosis of Parkinson disease (PD) is difficult in early stages of disease, with high
risk of misdiagnosis. The long preclinical phase of PD provides the possibility for early …
risk of misdiagnosis. The long preclinical phase of PD provides the possibility for early …
Amyloid-β and Parkinson's disease
EW Lim, D Aarsland, D Ffytche, RN Taddei… - Journal of …, 2019 - Springer
Parkinson's disease (PD) is the second commonest neurodegenerative disorder in the world
with a rising prevalence. The pathophysiology is multifactorial but aggregation of misfolded …
with a rising prevalence. The pathophysiology is multifactorial but aggregation of misfolded …
Evolution of Alzheimer's disease cerebrospinal fluid biomarkers in early Parkinson's disease
Objective We analyzed the longitudinal profile of Alzheimer's disease (AD) cerebrospinal
fluid (CSF) biomarkers in early Parkinson's disease (PD) compared with healthy controls …
fluid (CSF) biomarkers in early Parkinson's disease (PD) compared with healthy controls …
Gait and balance in Parkinson's disease subtypes: objective measures and classification considerations
T Herman, A Weiss, M Brozgol, N Giladi… - Journal of …, 2014 - Springer
Parkinson's disease (PD) is often divided into tremor dominant (TD) and postural instability
gait difficulty (PIGD) subtypes. However, objective measures of gait (eg, stride length …
gait difficulty (PIGD) subtypes. However, objective measures of gait (eg, stride length …
[HTML][HTML] Cognition and gait show a selective pattern of association dominated by phenotype in incident Parkinson's disease
Reports outlining the association between gait and cognition in Parkinson's disease (PD)
are limited because of methodological issues and a bias toward studying advanced disease …
are limited because of methodological issues and a bias toward studying advanced disease …
[HTML][HTML] Cerebrospinal fluid biochemical studies in patients with Parkinson's disease: toward a potential search for biomarkers for this disease
FJ Jiménez-Jiménez, H Alonso-Navarro… - Frontiers in cellular …, 2014 - frontiersin.org
The blood-brain barrier supplies brain tissues with nutrients and filters certain compounds
from the brain back to the bloodstream. In several neurodegenerative diseases, including …
from the brain back to the bloodstream. In several neurodegenerative diseases, including …