Inflammatory bowel disease (IBD) is a chronic and recurrent inflammatory disorder that
primarily comprises Crohn's disease (CD) and ulcerative colitis (UC). Owing to its increasing …

Abstract Yes-associated protein (YAP)/WW domain-containing transcription regulator 1
(TAZ) is an important transcriptional regulator and effector of the Hippo signaling pathway …

Introduction Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's
disease (CD), is a group of chronic recurrent and incurable gastrointestinal diseases with an …

Senescent astrocytes accumulate with aging and contribute to brain dysfunction and
diseases such as Alzheimer's disease (AD), however, the mechanisms underlying the …

Colon cancer (CC) is the third common neoplasm worldwide, and it is still a big challenge for
exploring new effective medicine for treating CC. Natural product promoting human health …

Osteoarthritis (OA) is a chronic disease affecting the whole joint, which still lacks a disease-
modifying treatment. This suggests an incomplete understanding of underlying molecular …

Animal models for colitis-associated colorectal cancer (CACC) represent an important tool to
explore the mechanistic basis of cancer-related inflammation, providing important evidence …

Lung cancer is one of the cancers with highest morbidity and mortality rates and the
metastasis of lung cancer is a leading cause of death. Mechanisms of lung cancer …

Leucine-rich repeat containing G protein-coupled receptor 5 (Lgr5), a marker of intestinal
stem cells (ISCs), is considered to play key roles in tissue homoeostasis and regeneration …

REGγ, a proteasome activator belonging to the 11S (otherwise known as REG, PA28, or
PSME) proteasome activator family, is widely present in many eukaryotes. By binding to the …