[HTML][HTML] Beyond t test and ANOVA: applications of mixed-effects models for more rigorous statistical analysis in neuroscience research

Z Yu, M Guindani, SF Grieco, L Chen, TC Holmes, X Xu - Neuron, 2022 - cell.com
In basic neuroscience research, data are often clustered or collected with repeated
measures, hence correlated. The most widely used methods such as t test and ANOVA do …

Interpreting and understanding logits, probits, and other nonlinear probability models

R Breen, KB Karlson, A Holm - annual review of sociology, 2018 - annualreviews.org
Methods textbooks in sociology and other social sciences routinely recommend the use of
the logit or probit model when an outcome variable is binary, an ordered logit or ordered …

Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity

P Akbari, A Gilani, O Sosina, JA Kosmicki, L Khrimian… - Science, 2021 - science.org
INTRODUCTION Obesity accounts for a substantial and growing burden of disease globally.
Body adiposity is highly heritable, and human genetic studies can lead to biological and …

Critical Period After Stroke Study (CPASS): A phase II clinical trial testing an optimal time for motor recovery after stroke in humans

AW Dromerick, S Geed, J Barth… - Proceedings of the …, 2021 - National Acad Sciences
Restoration of human brain function after injury is a signal challenge for translational
neuroscience. Rodent stroke recovery studies identify an optimal or sensitive period for …

[HTML][HTML] SARS-CoV-2 B. 1.1. 529 (Omicron) variant transmission within households—four US jurisdictions, November 2021–February 2022

JM Baker - MMWR. Morbidity and mortality weekly report, 2022 - cdc.gov
In a study of household transmission in four US jurisdictions, Omicron infection resulted in
high transmission among household contacts, particularly among those who lived with index …

Efficacy and safety of Paxlovid in severe adult patients with SARS-Cov-2 infection: a multicenter randomized controlled study

J Liu, X Pan, S Zhang, M Li, K Ma, C Fan… - The Lancet Regional …, 2023 - thelancet.com
Summary Background Nirmatrelvir plus ritonavir (Paxlovid) reduced the risk of
hospitalization or death by 89% in high-risk, ambulatory adults with COVID-19. We aimed at …

The coefficient of determination R2 and intra-class correlation coefficient from generalized linear mixed-effects models revisited and expanded

S Nakagawa, PCD Johnson… - Journal of the Royal …, 2017 - royalsocietypublishing.org
The coefficient of determination R 2 quantifies the proportion of variance explained by a
statistical model and is an important summary statistic of biological interest. However …

MAFLD better predicts the progression of atherosclerotic cardiovascular risk than NAFLD: generalized estimating equation approach

T Tsutsumi, M Eslam, T Kawaguchi… - Hepatology …, 2021 - Wiley Online Library
Aim Metabolic associated fatty liver disease (MAFLD) partly overlaps with non‐alcoholic fatty
liver disease (NAFLD). Thus, using a generalized estimating equation (GEE) approach, we …

Household transmission of severe acute respiratory syndrome coronavirus-2 in the United States

NM Lewis, VT Chu, D Ye, EE Conners… - Clinical Infectious …, 2021 - academic.oup.com
Background The evidence base for severe acute respiratory syndrome coronavirus-2 (SARS-
CoV-2) is nascent. We sought to characterize SARS-CoV-2 transmission within US …

Intermediate and advanced topics in multilevel logistic regression analysis

PC Austin, J Merlo - Statistics in medicine, 2017 - Wiley Online Library
Multilevel data occur frequently in health services, population and public health, and
epidemiologic research. In such research, binary outcomes are common. Multilevel logistic …