Opioid overdose is the leading cause of death for Americans 25 to 64 years of age, and
opioid use disorder affects> 2 million Americans. The epidemiology of opioid-associated out …

The opioid G-protein coupled receptors (GPCRs) strongly modulate many of the central
nervous system structures that contribute to major neurological and psychiatric disorders …

Opioids are potent respiratory depressants, and overdose is a leading cause of death
among people who use them. Worldwide, an estimated 69 000 people die from opioid …

This paper is the thirty-sixth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2013 …

Opioid misuse is endemic in the United States. In a 2017 survey, an estimated 11.4 million
Americans (4.2% of US persons aged 12 years or older) reported opioid misuse in the past …

Methadone is used as a substitution drug for the treatment of opioid dependence and
chronic pain. Despite its widespread use and availability, there is a serious concern with …

The appropriate prescribing of opioids requires an in-depth understanding of the
pharmacology and pharmacokinetics of these broad-spectrum analgesics. This chapter …

Methods: This cross sectional study was carried out on children under the age of 12 years
presenting to ED of a poisoning referral center. Demographic characteristics of the child and …

Naltrexone/Bupropion extended release (ER; Contrave) is an extended-release, fixed-dose
combination medication of naltrexone (8 mg) and bupropion (90 mg) for patients with obesity …

Background: Methadone toxicity is one of the major causes of death in opioiddependent
individuals. Objective: We aimed to compare two different protocols of naloxone …