Cancer biomarkers have transformed current practices in the oncology clinic. Continued
discovery and validation are crucial for improving early diagnosis, risk stratification, and …

The eukaryotic cell is compartmentalized into subcellular niches, including membrane-
bound and membrane-less organelles. Proteins localize to these niches to fulfil their …

To provide a detailed analysis of the molecular components and underlying mechanisms
associated with ovarian cancer, we performed a comprehensive mass-spectrometry-based …

Extensive genomic characterization of human cancers presents the problem of inference
from genomic abnormalities to cancer phenotypes. To address this problem, we analysed …

Although most tissues in an organism are genetically identical, the biochemistry of each is
optimized to fulfill its unique physiological roles, with important consequences for human …

The microbiome is being characterized by large-scale sequencing efforts, yet it is not known
whether it regulates host metabolism in a general versus tissue-specific manner or which …

Quantitative mass spectrometry methods offer near-comprehensive proteome coverage;
however, these methods still suffer with regards to sample throughput. Multiplex quantitation …

DNA sequencing has identified recurrent mutations that drive the aggressiveness of prostate
cancers. Surprisingly, the influence of genomic, epigenomic, and transcriptomic …

The study of protein localisation has greatly benefited from high-throughput methods
utilising cellular fractionation and proteomic profiling. Hyperplexed Localisation of Organelle …

Mitochondria are complex organelles whose dysfunction underlies a broad spectrum of
human diseases. Identifying all of the proteins resident in this organelle and understanding …