In eukaryotic cells, the nucleus contains the genome and is the site of transcriptional
regulation. The nucleus is the largest and stiffest organelle and is exposed to mechanical …

The nucleus is the distinguishing feature of eukaryotic cells. Until recently, it was often
considered simply as a unique compartment containing the genetic information of the cell …

While global chromatin conformation studies are emerging, very little is known about the
chromatin conformation of human telomeres. Most studies have focused on the role of …

A systems understanding of nuclear organization and events is critical for determining how
cells divide, differentiate, and respond to stimuli and for identifying the causes of diseases …

The actin cytoskeleton is one of the major structural components of the cell. It often
undergoes rapid reorganization and plays crucial roles in a number of dynamic cellular …

Although the role of liganded nuclear receptors in mediating coactivator/corepressor
exchange is well-established, little is known about the potential regulation of chromosomal …

Actin participates in several essential processes in the cell nucleus. Even though the
presence of actin in the nucleus was proposed more than 30 years ago, nuclear processes …

Over the past two decades, the biomechanical properties of cells have emerged as key
players in a broad range of cellular functions, including migration, proliferation, and …

The mystery of nuclear actin has puzzled biologists for decades largely due to the lack of
defined experimental systems. However, the development of actin-containing chromatin …

The nucleolus is the most obvious and clearly differentiated nuclear subcompartment. It is
where ribosome biogenesis takes place and has been the subject of research over many …