Macroautophagy (referred to here as autophagy) is induced by starvation to capture and
degrade intracellular proteins and organelles in lysosomes, which recycles intracellular …

Cells use mitophagy to remove dysfunctional or excess mitochondria, frequently in response
to imposed stresses, such as hypoxia and nutrient deprivation. Mitochondrial cargo …

In the past years, we have learnt that tumors co-evolve with their microenvironment, and that
the active interaction between cancer cells and stromal cells plays a pivotal role in cancer …

Metabolic reprogramming in tumours is now recognized as a hallmark of cancer,
participating both in tumour growth and cancer progression. Cancer cells develop global …

BN ip3 is a hypoxia‐inducible protein that targets mitochondria for autophagosomal
degradation. We report a novel tumor suppressor role for BN ip3 in a clinically relevant …

A better understanding of drug resistance mechanisms is required to improve outcomes in
patients with pancreatic cancer. Here, we characterized patterns of sensitivity and resistance …

Mammalian cells use a specialized and complex machinery for the removal of altered
proteins or dysfunctional organelles. Such machinery is part of a mechanism called …

Gene therapy, which involves replacement of a defective gene with a functional, healthy
copy of that gene, is a potentially beneficial cancer treatment approach particularly over …

Mitophagy is a selective form of macro-autophagy in which mitochondria are selectively
targeted for degradation in autophagolysosomes. Mitophagy can have the beneficial effect …

There are numerous studies that suggest multiple links between the cellular
phosphoinositide system and cancer. As key roles in cancer have been established for PI3K …