Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

Covering: up to 2022 Pentacyclic triterpenoids are important natural bioactive substances
that are widely present in plants and fungi. They have significant medicinal efficacy, play an …

Engineering cell metabolism for bioproduction not only consumes building blocks and
energy molecules (eg, ATP) but also triggers energetic inefficiency inside the cell. The …

Whole-cell biocatalysts provide unique advantages and have been widely used for the
efficient biosynthesis of value-added fine and bulk chemicals, as well as pharmaceutically …

Recent developments in synthetic biology, combined with continued progress in systems
biology and metabolic engineering, have enabled the engineering of microorganisms to …

Astrocytes metabolically interact with neighboring neurons by providing multiple substances
to neurons. How astrocytes regulate neural functions via altering the neuronal metabolic …

Malaria, caused by Plasmodium sp, results in almost one million deaths and over 200
million new infections annually. The World Health Organization has recommended that …

Heterologous pathways used in metabolic engineering may produce intermediates toxic to
the cell. Dynamic control of pathway enzymes could prevent the accumulation of these …

Engineered metabolic pathways constructed from enzymes heterologous to the production
host often suffer from flux imbalances, as they typically lack the regulatory mechanisms …

Microbial fatty acid-derived fuels have emerged as promising alternatives to petroleum-
based transportation fuels. Here we report a modular engineering approach that …