Infection of the colon with the Gram-positive bacterium Clostridium difficile is potentially life
threatening, especially in elderly people and in patients who have dysbiosis of the gut …

Clostridium difficile is a formidable nosocomial and community-acquired pathogen, causing
clinical presentations ranging from asymptomatic colonization to self-limiting diarrhea to …

Clostridium difficile infection (CDI) is the leading cause of antimicrobial and health care-
associated diarrhea in humans, presenting a significant burden to global health care …

Clostridium difficile infection is the leading cause of antibiotic-and healthcare-associated
diarrhea, and its containment and treatment imposes a significant financial burden …

Symptomatic recurrence of Clostridium difficile infection (CDI) occurs in approximately 20%
of patients and is challenging to treat. Identifying those at high risk could allow targeted …

Clostridium difficile is a Gram-positive, sporogenic and anaerobic bacterium that causes a
potentially fatal colitis. C. difficile enters the body as dormant spores that germinate in the …

Endosporulation is an ancient bacterial developmental program that culminates with the
differentiation of a highly resistant endospore. In the model organism Bacillus subtilis, gene …

Fidaxomicin (FDX) is a novel antimicrobial agent with narrow-spectrum and potent
bactericidal activity against Clostridium difficile. In recent clinical trials, FDX was superior to …

Clostridium difficile spores play a pivotal role in the transmission of infectious diarrhoea, but
in order to cause disease spores must complete germination and return to vegetative cell …

Clostridium difficile is a Gram-positive, spore-forming, human and animal pathogen that is
the major cause of antibiotic-associated diarrhoea worldwide. The past decade has seen the …