Trauma can affect any individual at any location and at any time over a lifespan. The
disruption of macrobarriers and microbarriers induces instant activation of innate immunity …

Multiple organ dysfunction syndrome (MODS) is one of the most common syndromes of
critical illness and the leading cause of mortality among critically ill patients. Multiple organ …

Objective: The aim of this study was to identify the effects of recent innovations in trauma
major hemorrhage management on outcome and transfusion practice, and to determine the …

Trauma hemorrhage is a leading cause of death and disability worldwide. Platelets are
fundamental to primary hemostasis, but become profoundly dysfunctional in critically injured …

Over the years, many explanations have been put forward to explain early and late deaths
following hemorrhagic trauma. Most include single-event, sequential contributions from …

Background Trauma leads to a complex inflammatory cascade that induces both immune
activation and a refractory immune state in parallel. Although both components are deemed …

Multiorgan dysfunction syndrome (MODS) remains a major complication and challenge to
treat patients with critical illness in different intensive care unit settings. The exact …

Platelets are damage sentinels of the intravascular compartment, initiating and coordinating
the primary response to tissue injury. Severe trauma and hemorrhage induce profound …

Immune dysfunction is an important factor driving mortality and adverse outcomes after
trauma but remains poorly understood, especially at the cellular level. To deconvolute the …

Associated with the development of hospital-acquired infections, major traumatic injury
results in an immediate and persistent state of systemic immunosuppression, yet the …