[HTML][HTML] Chemical penetration enhancers in stratum corneum—Relation between molecular effects and barrier function
Skin is attractive for drug therapy because it offers an easily accessible route without first-
pass metabolism. Transdermal drug delivery is also associated with high patient compliance …
pass metabolism. Transdermal drug delivery is also associated with high patient compliance …
Ceramides in the skin lipid membranes: length matters
B Skolova, B Janusova, J Zbytovska, G Gooris… - Langmuir, 2013 - ACS Publications
Ceramides are essential constituents of the skin barrier that allow humans to live on dry
land. Reduced levels of ceramides have been associated with skin diseases, eg, atopic …
land. Reduced levels of ceramides have been associated with skin diseases, eg, atopic …
[HTML][HTML] What can we learn about amphiphile-membrane interaction from model lipid membranes?
Surface-active amphiphiles find applications in a wide range of areas of industry such as
agrochemicals, personal care, and pharmaceuticals. In many of these applications …
agrochemicals, personal care, and pharmaceuticals. In many of these applications …
Establishing the impact of model surfactants on cloud condensation nuclei activity of sea spray aerosol mimics
SD Forestieri, SM Staudt, TM Kuborn… - Atmospheric …, 2018 - acp.copernicus.org
Surface-active compounds present in aerosols can increase their cloud condensation nuclei
(CCN) activation efficiency by reducing the surface tension (σ) in the growing droplets …
(CCN) activation efficiency by reducing the surface tension (σ) in the growing droplets …
Time-Dependent Differences in the Effects of Oleic Acid and Oleyl Alcohol on the Human Skin Barrier
A Kováčik, M Kopečná, I Hrdinová… - Molecular …, 2023 - ACS Publications
Oleic acid and oleyl alcohol are commonly used permeation and penetration enhancers to
facilitate topical drug delivery. Here, we aimed to better understand the mechanism of their …
facilitate topical drug delivery. Here, we aimed to better understand the mechanism of their …
Simulation study of the structure and phase behavior of ceramide bilayers and the role of lipid headgroup chemistry
S Guo, TC Moore, CR Iacovella… - Journal of chemical …, 2013 - ACS Publications
Ceramides are known to be a key component of the stratum corneum, the outermost
protective layer of the skin that controls barrier function. In this work, molecular dynamics …
protective layer of the skin that controls barrier function. In this work, molecular dynamics …
Remodelling of primary human CD4+ T cell plasma membrane order by n-3 PUFA
Cell membrane fatty acids influence fundamental properties of the plasma membrane,
including membrane fluidity, protein functionality, and lipid raft signalling. Evidence suggests …
including membrane fluidity, protein functionality, and lipid raft signalling. Evidence suggests …
Non-ionic surfactants as innovative skin penetration enhancers: Insight in the mechanism of interaction with simple 2D stratum corneum model system
Transdermal drug delivery is a passive diffusion process of an active compound through the
skin which is affected by drug solubility in the multilamellar lipidic matrix of the stratum …
skin which is affected by drug solubility in the multilamellar lipidic matrix of the stratum …
The effects of size and surface functionalization of polystyrene nanoplastics on stratum corneum model membranes: An experimental and computational study
S Cheng, J Hu, C Guo, Z Ye, Y Shang, C Lian… - Journal of Colloid and …, 2023 - Elsevier
Nanoplastics are mainly generated from the decomposition of plastic waste and artificial
production and have attracted much attention due to their wide distribution in the …
production and have attracted much attention due to their wide distribution in the …
Developmental changes in skin barrier and structure during the first 5 years of life
The structure of the stratum corneum (SC) and the corresponding skin barrier develops from
before birth up to about 4 years of age. Large subject-to-subject variability within an age …
before birth up to about 4 years of age. Large subject-to-subject variability within an age …