Genomic complexity of multiple myeloma and its clinical implications
Multiple myeloma (MM) is a genetically complex disease that evolves from pre-malignant
stages, such as monoclonal gammaopathy of undetermined significance and smouldering …
stages, such as monoclonal gammaopathy of undetermined significance and smouldering …
OF THE WORLD HEALTH ORGANIZATION CLASSIFICATION OF TUMORS OF THE HEMATOPOIETIC AND LYMPHOID TISSUES
This manuscript represents a review of lymphoblastic leukemia/lymphoma (acute
lymphoblastic leukemia/lymphoblastic lymphoma), acute leukemias of ambiguous lineage …
lymphoblastic leukemia/lymphoblastic lymphoma), acute leukemias of ambiguous lineage …
Treatment of multiple myeloma with high-risk cytogenetics: a consensus of the International Myeloma Working Group
P Sonneveld, H Avet-Loiseau, S Lonial… - Blood, The Journal …, 2016 - ashpublications.org
Abstract The International Myeloma Working Group consensus updates the definition for
high-risk (HR) multiple myeloma based on cytogenetics Several cytogenetic abnormalities …
high-risk (HR) multiple myeloma based on cytogenetics Several cytogenetic abnormalities …
Co-evolution of tumor and immune cells during progression of multiple myeloma
Multiple myeloma (MM) is characterized by the uncontrolled proliferation of plasma cells.
Despite recent treatment advances, it is still incurable as disease progression is not fully …
Despite recent treatment advances, it is still incurable as disease progression is not fully …
Management of newly diagnosed symptomatic multiple myeloma: updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) consensus …
Multiple myeloma remains an incurable neoplasm of plasma cells that affects more than
20,000 people annually in the United States. There has been a veritable revolution in this …
20,000 people annually in the United States. There has been a veritable revolution in this …
A simple additive staging system for newly diagnosed multiple myeloma
Risk stratification in multiple myeloma is important for prognostication, patient selection for
clinical trials, and comparison of treatment approaches. We developed and validated a …
clinical trials, and comparison of treatment approaches. We developed and validated a …
International Myeloma Working Group molecular classification of multiple myeloma: spotlight review
Myeloma is a malignant proliferation of monoclonal plasma cells. Although morphologically
similar, several subtypes of the disease have been identified at the genetic and molecular …
similar, several subtypes of the disease have been identified at the genetic and molecular …
Administration of bortezomib before and after autologous stem cell transplantation improves outcome in multiple myeloma patients with deletion 17p
K Neben, HM Lokhorst, A Jauch… - Blood, The Journal …, 2012 - ashpublications.org
In patients with multiple myeloma (MM), risk stratification by chromosomal abnormalities may
enable a more rational selection of therapeutic approaches. In the present study, we …
enable a more rational selection of therapeutic approaches. In the present study, we …
A novel prognostic model in myeloma based on co-segregating adverse FISH lesions and the ISS: analysis of patients treated in the MRC Myeloma IX trial
KD Boyd, FM Ross, L Chiecchio, GP Dagrada, ZJ Konn… - Leukemia, 2012 - nature.com
The association of genetic lesions detected by fluorescence in situ hybridization (FISH) with
survival was analyzed in 1069 patients with newly presenting myeloma treated in the …
survival was analyzed in 1069 patients with newly presenting myeloma treated in the …
A compendium of myeloma-associated chromosomal copy number abnormalities and their prognostic value
To obtain a comprehensive genomic profile of presenting multiple myeloma cases we
performed high-resolution single nucleotide polymorphism mapping array analysis in 114 …
performed high-resolution single nucleotide polymorphism mapping array analysis in 114 …