In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …

The maintenance of iron homeostasis is essential for proper cardiac function. A growing
body of evidence suggests that iron imbalance is the common denominator in many …

An abundant metal in the human body, iron is essential for key biological pathways
including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound …

Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

Cancer metabolism is rewired to support cell survival in response to intrinsic and
environmental stressors. Identification of strategies to target these adaptions is an area of …

Ferroptosis is a form of regulated cell death that emerges to be relevant for therapy-resistant
and dedifferentiating cancers. Although several lines of evidence suggest that ferroptosis is …

Iron is a critical element for living cells in terrestrial life. Although iron metabolism is strictly
controlled in the body, disturbance of iron homeostasis under certain type of condition leads …

For nearly 50 years the proximal tubule (PT) has been known to reabsorb, process, and
either catabolize or transcytose albumin from the glomerular filtrate. Innovative techniques …

Microglia are the resident innate immune cells in the brain with a major role in orchestrating
immune responses. They also provide a frontline of host defense in the central nervous …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal
neurodegenerative disorders that are thought to exist on a clinical and pathological …