Antioxidant curcumin induces oxidative stress to kill tumor cells

Y Hu, L Cheng, S Du, K Wang… - Oncology Letters, 2023 - spandidos-publications.com
Curcumin is a plant polyphenol in turmeric root and a potent antioxidant. It binds to
antioxidant response elements for gene regulation by nuclear factor erythroid 2-related …

[HTML][HTML] Ferroptosis regulation by Cap'n'collar family transcription factors

MB Murray, SJ Dixon - Journal of Biological Chemistry, 2024 - Elsevier
Ferroptosis is an iron-dependent cell death mechanism that may be important to prevent
tumor formation and useful as a target for new cancer therapies. Transcriptional networks …

Biogenic selenium nanoparticles synthesized using alginate oligosaccharides attenuate heat stress-induced impairment of breast meat quality via regulating oxidative …

YY Yang, YC An, SY Zhang, MY Huang, XQ Ye… - Antioxidants, 2023 - mdpi.com
Selenium (Se) is an indispensable trace element with versatile functions in antioxidant
defense in poultry. In our previous study, we synthesized a novel type of biogenic selenium …

GPCR-Gα13 involvement in mitochondrial function, oxidative stress, and prostate cancer

D Wu, PJ Casey - International Journal of Molecular Sciences, 2024 - mdpi.com
Gα13 and Gα12, encoded by the GNA13 and GNA12 genes, respectively, are members of
the G12 family of Gα proteins that, along with their associated Gβγ subunits, mediate …

Induced Ferroptosis Pathway by Regulating Cellular Lipid Peroxidation With Peroxynitrite Generator for Reversing “Cold” Tumors

R Li, H Yuan, C Zhang, D Han, Y Wang, L Feng - Small, 2024 - Wiley Online Library
Overcoming the resistance of tumor cells to apoptosis and immunosuppression is an
important challenge to improve tumor immunotherapy. Non‐apoptotic death mode of …

Role of ferroptosis in the pathogenesis of heart disease

S Fatima, H Zhou, Y Chen, Q Liu - Frontiers in Physiology, 2024 - frontiersin.org
Ferroptosis is a new form of regulated necrosis characterized by iron-dependent lipid
peroxidation, leading to irreparable lipid damage, membrane permeabilization, and necrotic …

[HTML][HTML] The complex interplay between ferroptosis and atherosclerosis

M Zhang, J Li, W Hu - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Atherosclerosis, characterized by the accumulation of plaque within the arterial walls, is an
intricate cardiovascular disease that often results in severe health issues. Recent studies …

Exogenous Iron Induces Mitochondrial Lipid Peroxidation, Lipofuscin Accumulation, and Ferroptosis in H9c2 Cardiomyocytes

KG Lyamzaev, H Huan, AA Panteleeva, RA Simonyan… - Biomolecules, 2024 - mdpi.com
Lipid peroxidation plays an important role in various pathologies and aging, at least partially
mediated by ferroptosis. The role of mitochondrial lipid peroxidation during ferroptosis …

SIRT1-FOXOs signaling pathway: A potential target for attenuating cardiomyopathy

C Lu, C Gao, J Wei, D Dong, M Sun - Cellular Signalling, 2024 - Elsevier
Cardiomyopathy constitutes a global health burden. It refers to myocardial injury that causes
alterations in cardiac structure and function, ultimately leading to heart failure. Currently …

DMT1 knockout abolishes ferroptosis induced mitochondrial dysfunction in C. elegans amyloid β proteotoxicity

W Peng, KB Chung, BP Lawrence, MK O'Banion… - Free Radical Biology …, 2024 - Elsevier
Iron is critical for neuronal activity and metabolism, and iron dysregulation alters these
functions in age-related neurodegenerative disorders, such as Alzheimer's disease (AD). AD …