Anti-amyloid antibody therapies in Alzheimer's disease
After years of failed attempts to develop a disease-modifying therapy for Alzheimer's
disease, consistent evidence in support of clinical efficacy was finally presented for a …
disease, consistent evidence in support of clinical efficacy was finally presented for a …
Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors
C Wang, DM Holtzman - Neuropsychopharmacology, 2020 - nature.com
As we age, we experience changes in our nighttime sleep and daytime wakefulness.
Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems even before …
Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems even before …
Sleep disturbance forecasts β-amyloid accumulation across subsequent years
Experimental sleep-wake disruption in rodents and humans causally modulates β-amyloid
(Aβ) dynamics (eg,[1–3]). This leads to the hypothesis that, beyond cross-sectional …
(Aβ) dynamics (eg,[1–3]). This leads to the hypothesis that, beyond cross-sectional …
Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans
How are memories transferred from short-term to long-term storage? Systems-level memory
consolidation is thought to be dependent on the coordinated interplay of cortical slow waves …
consolidation is thought to be dependent on the coordinated interplay of cortical slow waves …
Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer's disease
Sleep monitoring may provide markers for future Alzheimer's disease; however, the
relationship between sleep and cognitive function in preclinical and early symptomatic …
relationship between sleep and cognitive function in preclinical and early symptomatic …
Slow oscillation-spindle coupling predicts enhanced memory formation from childhood to adolescence
Precise temporal coordination of slow oscillations (SO) and sleep spindles is a fundamental
mechanism of sleep-dependent memory consolidation. SO and spindle morphology …
mechanism of sleep-dependent memory consolidation. SO and spindle morphology …
[HTML][HTML] It's complicated: The relationship between sleep and Alzheimer's disease in humans
BP Lucey - Neurobiology of disease, 2020 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by an
asymptomatic period of amyloid-β (Aβ) deposition as insoluble extracellular plaque …
asymptomatic period of amyloid-β (Aβ) deposition as insoluble extracellular plaque …
[HTML][HTML] Obstructive sleep apnea and its treatment in aging: effects on Alzheimer's disease biomarkers, cognition, brain structure and neurophysiology
Here we review the impact of obstructive sleep apnea (OSA) on biomarkers of Alzheimer's
disease (AD) pathogenesis, neuroanatomy, cognition and neurophysiology, and present the …
disease (AD) pathogenesis, neuroanatomy, cognition and neurophysiology, and present the …
Cleaning the sleeping brain–the potential restorative function of the glymphatic system
NL Hauglund, C Pavan, M Nedergaard - Current Opinion in Physiology, 2020 - Elsevier
Sleep is vital and universal across all species studied, and lack of sleep has detrimental
consequences for the organism. A broadly accepted theory for the purpose of sleep has yet …
consequences for the organism. A broadly accepted theory for the purpose of sleep has yet …
NREM sleep as a novel protective cognitive reserve factor in the face of Alzheimer's disease pathology
Background Alzheimer's disease (AD) pathology impairs cognitive function. Yet some
individuals with high amounts of AD pathology suffer marked memory impairment, while …
individuals with high amounts of AD pathology suffer marked memory impairment, while …