Virus-like particle vaccinology, from bench to bedside

MO Mohsen, MF Bachmann - Cellular & molecular immunology, 2022 - nature.com
Virus-like particles (VLPs) have become key tools in biology, medicine and even
engineering. After their initial use to resolve viral structures at the atomic level, VLPs were …

Interaction between virus-like particles (VLPs) and pattern recognition receptors (PRRs) from dendritic cells (DCs): toward better engineering of VLPs

J Zepeda-Cervantes, JO Ramírez-Jarquín… - Frontiers in …, 2020 - frontiersin.org
Virus-like particles (VLPs) have been shown to be strong activators of dendritic cells (DCs).
DCs are the most potent antigen presenting cells (APCs) and their activation prompts the …

Past, present, and future of allergen immunotherapy vaccines

Y Dorofeeva, I Shilovskiy, I Tulaeva, M Focke‐Tejkl… - Allergy, 2021 - Wiley Online Library
Allergen‐specific immunotherapy (AIT) is an allergen‐specific form of treatment for patients
suffering from immunoglobulin E (IgE)‐associated allergy; the most common and important …

New routes and opportunities for modular construction of particulate vaccines: stick, click, and glue

KD Brune, M Howarth - Frontiers in immunology, 2018 - frontiersin.org
Vaccines based on virus-like particles (VLPs) can induce potent B cell responses. Some non-
chimeric VLP-based vaccines are highly successful licensed products (eg, hepatitis B …

Vaccine against peanut allergy based on engineered virus-like particles displaying single major peanut allergens

F Storni, A Zeltins, I Balke, MD Heath… - Journal of Allergy and …, 2020 - Elsevier
Background Peanut allergy is a severe and increasingly frequent disease with high medical,
psychosocial, and economic burden for affected patients and wider society. A causal, safe …

The 3Ds in virus‐like particle based‐vaccines: “Design, Delivery and Dynamics

MO Mohsen, G Augusto… - Immunological reviews, 2020 - Wiley Online Library
Vaccines need to be rationally designed in order be delivered to the immune system for
maximizing induction of dynamic immune responses. Virus‐like particles (VLPs) are ideal …

Perspectives in allergen immunotherapy: 2019 and beyond

O Pfaar, I Agache, F de Blay, S Bonini, AM Chaker… - Allergy, 2019 - Wiley Online Library
The seventh “Future of the Allergists and Specific Immunotherapy (FASIT)” workshop held in
2019 provided a platform for global experts from academia, allergy clinics, regulatory …

The next generation virus‐like particle platform for the treatment of peanut allergy

JM Sobczak, PS Krenger, F Storni, MO Mohsen… - Allergy, 2023 - Wiley Online Library
Background Allergy to peanut is one of the leading causes of anaphylactic reactions among
food allergic patients. Immunization against peanut allergy with a safe and protective …

State‐of‐the‐art in marketed adjuvants and formulations in allergen immunotherapy: a position paper of the European Academy of Allergy and Clinical Immunology …

E Jensen‐Jarolim, MF Bachmann, S Bonini… - Allergy, 2020 - Wiley Online Library
Since the introduction of allergen immunotherapy (AIT) over 100 years ago, focus has been
on standardization of allergen extracts, with reliable molecular composition of allergens …

[HTML][HTML] Immunization of cats to induce neutralizing antibodies against Fel d 1, the major feline allergen in human subjects

F Thoms, GT Jennings, M Maudrich, M Vogel… - Journal of Allergy and …, 2019 - Elsevier
Background Cat allergy in human subjects is usually caused by the major cat allergen Fel d
1 and is found in approximately 10% of the Western population. Currently, there is no …