The transcription factor and oncoprotein MYC is a potent driver of many human cancers and
can regulate numerous biological activities that contribute to tumorigenesis. How a single …

Multifaceted relations link ribosome biogenesis to cancer. Ribosome biogenesis takes place
in the nucleolus. Clarifying the mechanisms involved in this nucleolar function and its …

Although the MYC oncogene has been implicated in cancer, a systematic assessment of
alterations of MYC, related transcription factors, and co-regulatory proteins, forming the …

Metabolism generates oxygen radicals, which contribute to oncogenic mutations. Activated
oncogenes and loss of tumor suppressors in turn alter metabolism and induce aerobic …

The biosynthesis of ribosomes is a complex process that requires the coordinated action of
many factors and a huge energy investment from the cell. Ribosomes are essential for …

Abstract FBW7 (F-box and WD repeat domain-containing 7) is the substrate recognition
component of an evolutionary conserved SCF (complex of SKP1, CUL1 and F-box protein) …

That cancer cells show patterns of metabolism different from normal cells has been known
for over 50 years. Yet, it is only in the past decade or so that an appreciation of the benefits …

Ribosome biogenesis is a canonical hallmark of cell growth and proliferation. Here we show
that execution of Epithelial-to-Mesenchymal Transition (EMT), a migratory cellular program …

Ribosome biogenesis is a fundamental process that provides cells with the molecular
factories for cellular protein production. Accordingly, its misregulation lies at the heart of …

The contribution of the nucleolus to cancer is well established with respect to its traditional
role in facilitating ribosome biogenesis and proliferative capacity. More contemporary …