Production methods for hyaluronan

CG Boeriu, J Springer, FK Kooy… - International journal …, 2013 - Wiley Online Library
Hyaluronan is a polysaccharide with multiple functions in the human body being involved in
creating flexible and protective layers in tissues and in many signalling pathways during …

Transcriptional and post‐translational regulation of hyaluronan synthesis

RH Tammi, AG Passi, K Rilla, E Karousou… - The FEBS …, 2011 - Wiley Online Library
Hyaluronan, a ubiquitous high‐molecular‐mass glycinoglycan on cell surfaces and in
extracellular matrices, has a number of specific signaling functions in cell–cell …

Diverse roles for hyaluronan and hyaluronan receptors in the developing and adult nervous system

A Peters, LS Sherman - International journal of molecular sciences, 2020 - mdpi.com
Hyaluronic acid (HA) plays a vital role in the extracellular matrix of neural tissues. Originally
thought to hydrate tissues and provide mechanical support, it is now clear that HA is also a …

Hyaluronan synthesis is inhibited by adenosine monophosphate-activated protein kinase through the regulation of HAS2 activity in human aortic smooth muscle cells

D Vigetti, M Clerici, S Deleonibus, E Karousou… - Journal of Biological …, 2011 - ASBMB
Hyaluronan (HA) is an extracellular matrix glycosaminoglycan (GAG) involved in cell motility,
proliferation, tissue remodeling, development, differentiation, inflammation, tumor …

Three vertebrate hyaluronan synthases are expressed during mouse development in distinct spatial and temporal patterns

JYL Tien, AP Spicer - … dynamics: an official publication of the …, 2005 - Wiley Online Library
We have used in situ hybridization to study the expression of the vertebrate hyaluronan
synthase (Has) gene family members, designated Has1, Has2, and Has3, during mouse …

Molecular cloning and characterization of UDP-glucose dehydrogenase from the amphibian Xenopus laevis and its involvement in hyaluronan synthesis

D Vigetti, M Ori, M Viola, A Genasetti… - Journal of Biological …, 2006 - ASBMB
UDP-glucose dehydrogenase (UGDH) supplies the cell with UDP-glucuronic acid (UDP-
GlcUA), a precursor of glycosaminoglycan and proteoglycan synthesis. Here we reported …

[HTML][HTML] Prospective bacterial and fungal sources of hyaluronic acid: A review

EV Shikina, RA Kovalevsky, AI Shirkovskaya… - Computational and …, 2022 - Elsevier
The unique biological and rheological properties make hyaluronic acid a sought-after
material for medicine and cosmetology. Due to very high purity requirements for hyaluronic …

Regulation of hyaluronan synthesis in vascular diseases and diabetes

P Moretto, E Karousou, M Viola, I Caon… - Journal of diabetes …, 2015 - Wiley Online Library
Cell microenvironment has a critical role determining cell fate and modulating cell
responses to injuries. Hyaluronan (HA) is a ubiquitous extracellular matrix …

Renal interstitial hyaluronan: functional aspects during normal and pathological conditions

S Stridh, F Palm, P Hansell - American Journal of …, 2012 - journals.physiology.org
The glycosaminoglycan (GAG) hyaluronan (HA) is recognized as an important structural
component of the extracellular matrix, but it also interacts with cells during embryonic …

Metabolism and mechanisms of action of hyaluronan in human biology

RA Joy, N Vikkath, PS Ariyannur - Drug metabolism and …, 2018 - degruyter.com
Hyaluronan is a ubiquitous high-molecular weight polymer of repeated disaccharides of
glucuronic acid and N-acetylglucosamine. It is a membrane-bound, viscous material …