Fluorescence imaging of large-scale neural ensemble dynamics

TH Kim, MJ Schnitzer - Cell, 2022 - cell.com
Recent progress in fluorescence imaging allows neuroscientists to observe the dynamics of
thousands of individual neurons, identified genetically or by their connectivity, across …

Scanning fiber endoscopy with highly flexible, 1 mm catheterscopes for wide‐field, full‐color imaging

CM Lee, CJ Engelbrecht, TD Soper… - Journal of …, 2010 - Wiley Online Library
In modern endoscopy, wide field of view and full color are considered necessary for
navigating inside the body, inspecting tissue for disease and guiding interventions such as …

[HTML][HTML] Large-scale two-photon calcium imaging in freely moving mice

W Zong, HA Obenhaus, ER Skytøen, H Eneqvist… - Cell, 2022 - cell.com
We developed a miniaturized two-photon microscope (MINI2P) for fast, high-resolution,
multiplane calcium imaging of over 1,000 neurons at a time in freely moving mice. With a …

Miniature two-photon microscopy for enlarged field-of-view, multi-plane and long-term brain imaging

W Zong, R Wu, S Chen, J Wu, H Wang, Z Zhao… - Nature …, 2021 - nature.com
We have developed a miniature two-photon microscope equipped with an axial scanning
mechanism and a long-working-distance miniature objective to enable multi-plane imaging …

Miniature three-photon microscopy maximized for scattered fluorescence collection

C Zhao, S Chen, L Zhang, D Zhang, R Wu, Y Hu… - Nature …, 2023 - nature.com
In deep-tissue multiphoton microscopy, diffusion and scattering of fluorescent photons,
rather than ballistic emanation from the focal point, have been a confounding factor. Here we …

Handheld high-throughput plasmonic biosensor using computational on-chip imaging

AE Cetin, AF Coskun, BC Galarreta, M Huang… - Light: Science & …, 2014 - nature.com
We demonstrate a handheld on-chip biosensing technology that employs plasmonic
microarrays coupled with a lens-free computational imaging system towards multiplexed …

Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice

W Zong, R Wu, M Li, Y Hu, Y Li, J Li, H Rong, H Wu… - Nature …, 2017 - nature.com
Developments in miniaturized microscopes have enabled visualization of brain activities
and structural dynamics in animals engaging in self-determined behaviors. However, it …

All the light that we can see: a new era in miniaturized microscopy

D Aharoni, BS Khakh, AJ Silva, P Golshani - Nature methods, 2019 - nature.com
One major challenge in neuroscience is to uncover how defined neural circuits in the brain
encode, store, modify, and retrieve information. Meeting this challenge comprehensively …

Two‐photon excitation microscopy for the study of living cells and tissues

RKP Benninger, DW Piston - Current protocols in cell biology, 2013 - Wiley Online Library
Two‐photon excitation microscopy is an alternative to confocal microscopy that provides
advantages for three‐dimensional and deep tissue imaging. This unit will describe the basic …

Compact and flexible raster scanning multiphoton endoscope capable of imaging unstained tissue

DR Rivera, CM Brown, DG Ouzounov… - Proceedings of the …, 2011 - National Acad Sciences
We present a compact and flexible endoscope (3-mm outer diameter, 4-cm rigid length) that
utilizes a miniaturized resonant/nonresonant fiber raster scanner and a multielement …