[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?

M Kou, L Huang, J Yang, Z Chiang, S Chen, J Liu… - Cell death & …, 2022 - nature.com
Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone
marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and …

[HTML][HTML] Challenges and advances in clinical applications of mesenchymal stromal cells

T Zhou, Z Yuan, J Weng, D Pei, X Du, C He… - Journal of hematology & …, 2021 - Springer
Mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, have been
intensely investigated for clinical applications within the last decades. However, the majority …

[HTML][HTML] Engineering the next generation of cell-based therapeutics

CJ Bashor, IB Hilton, H Bandukwala… - Nature Reviews Drug …, 2022 - nature.com
Cell-based therapeutics are an emerging modality with the potential to treat many currently
intractable diseases through uniquely powerful modes of action. Despite notable recent …

[HTML][HTML] Molecular principles of metastasis: a hallmark of cancer revisited

J Fares, MY Fares, HH Khachfe, HA Salhab… - Signal transduction and …, 2020 - nature.com
Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-
related deaths. Yet, it remains poorly understood. The continuous evolution of cancer …

[HTML][HTML] Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries

T Zhao, W Wu, L Sui, Q Huang, Y Nan, J Liu, K Ai - Bioactive Materials, 2022 - Elsevier
Interventional coronary reperfusion strategies are widely adopted to treat acute myocardial
infarction, but morbidity and mortality of acute myocardial infarction are still high …

[HTML][HTML] Immunomodulation by mesenchymal stem cells (MSCs): mechanisms of action of living, apoptotic, and dead MSCs

ARR Weiss, MH Dahlke - Frontiers in immunology, 2019 - frontiersin.org
Expectations on mesenchymal stem cell (MSC) treatment are high, especially in the fields of
sepsis, transplant medicine, and autoimmune diseases. Various pre-clinical studies have …

A functional corona around extracellular vesicles enhances angiogenesis, skin regeneration and immunomodulation

M Wolf, RW Poupardin, P Ebner‐Peking… - Journal of …, 2022 - Wiley Online Library
Nanoparticles can acquire a plasma protein corona defining their biological identity. Corona
functions were previously considered for cell‐derived extracellular vesicles (EVs). Here we …

[HTML][HTML] Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies

NC Noronha, A Mizukami, C Caliári-Oliveira… - Stem cell research & …, 2019 - Springer
Multipotent mesenchymal stromal cells (MSC) have been widely explored for cell-based
therapy of immune-mediated, inflammatory, and degenerative diseases, due to their …

[PDF][PDF] Mesenchymal stromal cells: clinical challenges and therapeutic opportunities

J Galipeau, L Sensébé - Cell stem cell, 2018 - cell.com
Mesenchymal stromal cells (MSCs) have been the subject of clinical trials for more than a
generation, and the outcomes of advanced clinical trials have fallen short of expectations …

[HTML][HTML] Challenges and controversies in human mesenchymal stem cell therapy

B Lukomska, L Stanaszek, E Zuba-Surma… - Stem cells …, 2019 - hindawi.com
Stem cell therapy is being intensely investigated within the last years. Expectations are high
regarding mesenchymal stem cell (MSC) treatment in translational medicine. However …