[HTML][HTML] A systematic review of computational drug discovery, development, and repurposing for Ebola virus disease treatment
Ebola virus disease (EVD) is a deadly global public health threat, with no currently approved
treatments. Traditional drug discovery and development is too expensive and inefficient to …
treatments. Traditional drug discovery and development is too expensive and inefficient to …
[HTML][HTML] Machine learning models identify molecules active against the Ebola virus in vitro
The search for small molecule inhibitors of Ebola virus (EBOV) has led to several high
throughput screens over the past 3 years. These have identified a range of FDA-approved …
throughput screens over the past 3 years. These have identified a range of FDA-approved …
Filovirus proteins for antiviral drug discovery: Structure/function of proteins involved in assembly and budding
There are no approved medications for the treatment of Marburg or Ebola virus infection. In
two previous articles (Martin et al., 2016, Martin et al., 2017), we reviewed surface …
two previous articles (Martin et al., 2016, Martin et al., 2017), we reviewed surface …
[HTML][HTML] Integrated computational approach for virtual hit identification against ebola viral proteins VP35 and VP40
MU Mirza, N Ikram - International journal of molecular sciences, 2016 - mdpi.com
The Ebola virus (EBOV) has been recognised for nearly 40 years, with the most recent
EBOV outbreak being in West Africa, where it created a humanitarian crisis. Mortalities …
EBOV outbreak being in West Africa, where it created a humanitarian crisis. Mortalities …
[HTML][HTML] Molecular docking enabled updated screening of the matrix protein VP40 from Ebola virus with millions of compounds in the MCULE database for potential …
Ebola virus is known for several outbreaks of hemorrhagic fever in West Africa. This RNA
virus is linked to high fatality and easy transmission. Recently, an effective vaccine and a …
virus is linked to high fatality and easy transmission. Recently, an effective vaccine and a …
[HTML][HTML] Molecular docking based screening of compounds against VP40 from Ebola virus
Ebola virus causes severe and often fatal hemorrhagic fevers in humans. The 2014 Ebola
epidemic affected multiple countries. The virus matrix protein (VP40) plays a central role in …
epidemic affected multiple countries. The virus matrix protein (VP40) plays a central role in …
[HTML][HTML] Potential of Tryptamine Derivatives as Multi-Target Directed Ligands for Alzheimer's Disease: AChE, MAO-B, and COX-2 as Molecular Targets
Extensive research has been dedicated to develop compounds that can target multiple
aspects of Alzheimer's disease (AD) treatment due to a growing understanding of AD's …
aspects of Alzheimer's disease (AD) treatment due to a growing understanding of AD's …
Identification of novel inhibitors against VP40 protein of Marburg virus by integrating molecular modeling and dynamics approaches
Marburg virus (MV) is a highly etiological agent of haemorrhagic fever in humans and has
spread across the world. Its outbreaks caused a 23–90% human death rate. However, there …
spread across the world. Its outbreaks caused a 23–90% human death rate. However, there …
Identification of novel Ebola virus (EBOV) VP24 inhibitor from Indonesian natural products through in silico drug design approach
USF Tambunan, MAF Nasution - AIP Conference Proceedings, 2017 - pubs.aip.org
Ebola remains as one of the deadliest diseases in the world, with almost 29,000 cases were
reported and kill 11,000 of them, and yet neither treatment nor vaccine that can combat this …
reported and kill 11,000 of them, and yet neither treatment nor vaccine that can combat this …
Identification of Ebola virus inhibitors targeting GP2 using principles of molecular mimicry
ABSTRACT A key step in the Ebola virus (EBOV) replication cycle involves conformational
changes in viral glycoprotein 2 (GP2) which facilitate host-viral membrane fusion and …
changes in viral glycoprotein 2 (GP2) which facilitate host-viral membrane fusion and …