Atherosclerosis is a chronic disease of the arterial wall where both innate and adaptive
immunoinflammatory mechanisms are involved. Inflammation is central at all stages of …

Atherosclerosis is nowadays generally accepted as an inflammatory disease. It is known that
local inflammation occurs in the formation the plaques, as macrophages and other immuno …

Background—Unstable angina (UA) is associated with systemic inflammation and with
expansion of interferon-γ–producing T lymphocytes. The cause of T-cell activation and the …

Background The role of inflammation in patients with coronary artery disease is emerging.
We sought to assess the profile and outcomes of patients with a clinical syndrome of severe …

Acute coronary syndromes are responsible for most of the morbidity and mortality caused by
coronary atherosclerosis. Both unstable angina and acute myocardial infarction are …

Background—The CD40 ligand (CD40L) on activated T cells and platelets may be activating
matrix metalloproteinases, inducing procoagulant activity, and be involved in the …

Anti-inflammatory and immunomodulatory effects of statins. 3-Hydroxy-3-methyl-gutaryl
coenzyme A (HMG-CoA) reductase inhibitors or statins constitute the most powerful class of …

Extensive evidence supports a pathogenic role for both local and systemic inflammation in
acute coronary syndromes. However, several important questions remain unanswered. Is …

Activation of T lymphocytes and their ensuing elaboration of proinflammatory cytokines, such
as interferon (IFN)-γ, represent a critical step in atherogenesis and arteriosclerosis. IFNγ …

Far from being merely a passive cholesterol accumulation within the arterial wall, the
development of atherosclerosis is currently known to imply both inflammation and immune …