Brown and beige adipocytes can catabolize stored energy to generate heat, and this distinct
capacity for thermogenesis could be leveraged as a therapy for metabolic diseases like …

Mammals have two types of thermogenic adipocytes: brown adipocytes and beige
adipocytes. Thermogenic adipocytes express high levels of uncoupling protein 1 (UCP1) to …

Diet-induced thermogenesis is an important homeostatic mechanism that limits weight gain
in response to caloric excess and contributes to the relative stability of body weight in most …

Obesity and diabetes has become a major epidemic across the globe. Controlling obesity
has been a challenge since this would require either increased physical activity or reduced …

Obesity results from energy imbalance, when energy intake exceeds energy expenditure.
Brown adipose tissue (BAT) drives non-shivering thermogenesis which represents a …

Depleting creatine levels in thermogenic adipocytes by inhibiting creatine biosynthesis
reduces thermogenesis and causes obesity. However, whether creatine import from the …

The issue under discussion here is whether a decrease in the degree of UCP1 activity (and
brown adipose tissue activity in general) could be a cause of obesity in humans. This …

Thermogenesis in endotherms relies on both shivering and non-shivering thermogenesis
(NST). The role of brown adipose tissue (BAT) in NST is well recognized, but the role of …

In healthy muscle, the rapid release of calcium ions (Ca2+) with excitation–contraction (EC)
coupling, results in elevations in Ca2+ concentrations which can exceed 10-fold that of …

New Findings What is the topic of this review? It has been suggested that human brown
adipose tissue (BAT) is more similar to the brite/beige adipose tissue of mice than to …