The intestinal extracellular matrix (ECM) represents a complex network of proteins that not
only forms a support structure for resident cells but also interacts closely with them by …

Matrix metalloproteinases (MMPs) are identifiable members of proteolytic enzymes that can
degrade a wide range of proteins in the extracellular matrix (ECM). MMPs can be …

The tumor microenvironment (TME) is a complex and variable region characterized by
hypoxia, low pH, high redox status, overexpression of enzymes, and high‐adenosine …

Small molecules targeting the ubiquitous latent ribonuclease (RNase L), which has limited
sequence specificity toward single-stranded RNA substrates, hold great potential to be …

Matrix metalloproteinases (MMPs) play important roles in many diseases including cancer.
With moderate metal-binding affinity, 8-hydroxyquinoline has gained much interest in current …

The scaffold-based drug design has been widely used in new drug discovery. Biphenyl and
its analog scaffold are found in many drugs and naturally occurring compounds. To date an …

Matrix metalloproteinase 13 plays a central role in osteoarthritis (OA), as its overexpression
induces an excessive breakdown of collagen that results in an imbalance between collagen …

The proteolytic activity of the enzyme ADAMTS7 was recently shown to enhance the
progression of atherosclerosis, in line with human genetic findings suggesting that …

The metalloproteinase ADAM8 is upregulated in several cancers but has a dispensable
function under physiological conditions. In tumor cells, ADAM8 is involved in invasion …

The ADAMs belong to the Adamalysin family of zinc-dependent metalloproteinases. Some
ADAMs, as membrane-bound enzymes, are responsible for the ectodomain shedding of …