Increased body weight and metabolic disorder including insulin resistance, type 2 diabetes
and cardiovascular complications together constitute metabolic syndrome. The …

Proteins are major targets for radicals and two-electron oxidants in biological systems due to
their abundance and high rate constants for reaction. With highly reactive radicals damage …

Inflammation and oxidative stress (OS) are closely related processes, as well exemplified in
obesity and cardiovascular diseases. OS is also related to hormonal derangement in a …

Diabetes is a major public health disease that is globally approaching epidemic proportions.
One of the major causes of type 2 diabetes is either a defect in insulin secretion or insulin …

Reactive oxygen and nitrogen species (RONS) are essential for normal physiological
processes and play important roles in cell signaling, immunity, and tissue homeostasis …

In diabetes mellitus, the polyol pathway is highly active and consumes approximately 30%
glucose in the body. This pathway contains 2 reactions catalyzed by aldose reductase (AR) …

The extracellular matrix (ECM) is a key regulator of cell and tissue function. Traditionally, the
ECM has been thought of primarily as a physical scaffold that binds cells and tissues …

Increasing evidence in both experimental and clinical studies suggests that oxidative stress
plays a major role in the pathogenesis of both types of diabetes mellitus. Free radicals are …

Advanced oxidation protein products as a novel marker of oxidative stress in uremia.
Evidence suggests an imbalance between antioxidant and oxidant-generating systems …

Oxidative stress and oxidative damage to tissues are common end points of chronic
diseases, such as atherosclerosis, diabetes, and rheumatoid arthritis. The question …