Rationale: Current therapies for metastatic osseous disease frequently fail to provide a
durable treatment response. To date, there are only limited therapeutic options for metastatic …

Cancer is the second leading cause of death worldwide and has become a global burden. It
has long been known that inflammation is related to cancer, as inflammatory components …

Regions of hypoxia (low oxygen) occur in most solid tumours and cells in these areas are
the most aggressive and therapy resistant. In response to decreased oxygen, extensive …

Recent clinical trials in breast and prostate cancer have established that fewer, larger daily
doses (fractions) of radiotherapy are safe and effective, but these do not represent …

Hypoxia-induced replication stress is one of the most physiologically relevant signals known
to activate ATM in tumors. Recently, the ATM interactor (ATMIN) was identified as critical for …

Objective To investigate the anti-tumor activity and molecular mechanism of Tonglian
Decoction (通莲汤, TLD) on esophageal carcinoma Eca109 cells. Methods Eca109 cells …

Background Radiotherapy currently has become one of the major therapeutic approaches in
the treatments for cancers. However, hypoxia presents a significant challenge to the …

Platinum-based chemotherapeutics are used in many combination regimens in cancer.
Despite this popularity, there is room for improved efficacy and patient selection for …

Une série de composés synthétiques conçus pour inhiber l'Insulin-Degrading Enzyme (IDE)
augmentent la puissance d'induction de l'apoptose par des inhibiteurs du protéasome, tel …