International Union of Basic and Clinical Pharmacology. CV. Somatostatin receptors: structure, function, ligands, and new nomenclature

T Günther, G Tulipano, P Dournaud, C Bousquet… - Pharmacological …, 2018 - ASPET
Somatostatin, also known as somatotropin-release inhibitory factor, is a cyclopeptide that
exerts potent inhibitory actions on hormone secretion and neuronal excitability. Its …

Immunohistochemistry in the diagnosis and classification of neuroendocrine neoplasms: what can brown do for you?

AM Bellizzi - Human pathology, 2020 - Elsevier
This review is based on a presentation given at the Hans Popper Hepatopathology Society
companion meeting at the 2019 United States and Canadian Academy of Pathology Annual …

Role of biomarker tests for diagnosis of neuroendocrine tumours

J Hofland, WT Zandee, WW de Herder - Nature Reviews Endocrinology, 2018 - nature.com
Neuroendocrine tumours (NETs) are neoplasms that arise from neuroendocrine cells.
Neuroendocrine cells and their tumours can secrete a wide range of amines and …

Pancreatic neuroendocrine tumors: molecular mechanisms and therapeutic targets

CK Maharjan, PH Ear, CG Tran, JR Howe… - Cancers, 2021 - mdpi.com
Simple Summary Pancreatic neuroendocrine tumors (pNETs) are rare, indolent cancers
whose causation is only partly understood. An increasing number of studies have uncovered …

Role of somatostatin receptor in pancreatic neuroendocrine tumor development, diagnosis, and therapy

Y Hu, Z Ye, F Wang, Y Qin, X Xu, X Yu… - Frontiers in …, 2021 - frontiersin.org
Pancreatic neuroendocrine tumors (pNETs) are rare and part of the diverse family of
neuroendocrine neoplasms (NENs). Somatostatin receptors (SSTRs), which are widely …

Prognostic and predictive factors on overall survival and surgical outcomes in pancreatic neuroendocrine tumors: recent advances and controversies

L Lee, T Ito, RT Jensen - Expert review of anticancer therapy, 2019 - Taylor & Francis
Introduction: Recent advances in diagnostic modalities and therapeutic agents have raised
the importance of prognostic factors in predicting overall survival, as well as predictive …

Neuroendocrine neoplasms in the context of inherited tumor syndromes: a reappraisal focused on targeted therapies

RM Ruggeri, E Benevento, F De Cicco… - Journal of …, 2023 - Springer
Purpose Neuroendocrine neoplasms can occur as part of inherited disorders, usually in the
form of well-differentiated, slow-growing tumors (NET). The main predisposing syndromes …

[HTML][HTML] Radiomics-Based Texture Analysis of 68Ga-DOTATATE Positron Emission Tomography and Computed Tomography Images as a Prognostic Biomarker in Adults With …

C Atkinson, B Ganeshan, R Endozo, S Wan… - Frontiers in …, 2021 - frontiersin.org
Purpose Neuroendocrine tumors (NET) are rare cancers with variable behavior. A better
understanding of prognosis would aid individualized management. The aim of this …

Role of somatostatin signalling in neuroendocrine tumours

O Rogoza, K Megnis, M Kudrjavceva… - International Journal of …, 2022 - mdpi.com
Somatostatin (SST) is a small peptide that exerts inhibitory effects on a wide range of
neuroendocrine cells. Due to the fact that somatostatin regulates cell growth and hormone …

P53, Somatostatin receptor 2a and Chromogranin A immunostaining as prognostic markers in high grade gastroenteropancreatic neuroendocrine neoplasms

K Nielsen, T Binderup, SW Langer, A Kjaer, P Knigge… - BMC cancer, 2020 - Springer
Background High grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN)
with a Ki67 proliferation index> 20%, include well-differentiated tumours grade 3 (NET G3) …