[18F] MPPF as a tool for the in vivo imaging of 5-HT1A receptors in animal and human brain
N Aznavour, L Zimmer - Neuropharmacology, 2007 - Elsevier
Serotonin (5-hydroxytryptamine, 5-HT) and its various receptors are involved in numerous
CNS functions and psychiatric disorders. 5-HT1A, the best-characterized subtype of …
CNS functions and psychiatric disorders. 5-HT1A, the best-characterized subtype of …
PET tracers for 5-HT1A receptors and uses thereof
JSD Kumar, JJ Mann - Drug discovery today, 2007 - Elsevier
The serotonin 5-HT1A receptor is implicated in the pathophysiology of major
neuropsychiatric disorders, including depression, suicidal behavior, panic disorder …
neuropsychiatric disorders, including depression, suicidal behavior, panic disorder …
Acute treatment with the antidepressant fluoxetine internalizes 5-HT1A autoreceptors and reduces the in vivo binding of the PET radioligand [18F] MPPF in the …
Because 5-HT1A receptors located on the soma dendrites of serotonin (5-HT) neurons
normally mediate an inhibition of 5-HT firing and release, the desensitization of these …
normally mediate an inhibition of 5-HT firing and release, the desensitization of these …
Uptake and binding of the serotonin 5-HT1A antagonist [18F]-MPPF in brain of rats: effects of the novel P-glycoprotein inhibitor tariquidar
C La Fougere, G Böning, H Bartmann, B Wängler… - Neuroimage, 2010 - Elsevier
We used microPET to map the dose–response to the novel P-glycoprotein (P-gp) inhibitor
tariquidar (TQD) of the initial influx of the P-gp substrate [18F]-MPPF in rat brain, and to test …
tariquidar (TQD) of the initial influx of the P-gp substrate [18F]-MPPF in rat brain, and to test …
Arterial input function measurement without blood sampling using a β-microprobe in rats
F Pain, P Lanièce, R Mastrippolito… - Journal of Nuclear …, 2004 - Soc Nuclear Med
The evaluation of every new radiotracer involves pharmacokinetic studies on small animals
to determine its biodistribution and local kinetics. To extract relevant biochemical …
to determine its biodistribution and local kinetics. To extract relevant biochemical …
A PET imaging study of 5-HT1A receptors in cat brain after acute and chronic fluoxetine treatment
Immuno-electron microscopic and β-microprobe studies have demonstrated that the
internalization of serotonin 5-HT1A autoreceptors, after acute treatment with the selective 5 …
internalization of serotonin 5-HT1A autoreceptors, after acute treatment with the selective 5 …
Toward brain imaging of serotonin 5-HT1A autoreceptor internalization
Enhancing cerebral serotonin (5-hydroxytryptamine, 5-HT) neurotransmission is a common
property of antidepressant treatments and the basis for their efficacy. 5-HT1A receptors …
property of antidepressant treatments and the basis for their efficacy. 5-HT1A receptors …
A reduced extracellular serotonin level increases the 5-HT1A PET ligand 18F-MPPF binding in the rat hippocampus
4, 2′-(Methoxyphenyl)-1-[2′-(N-2 ″-pyridinyl)-p-fluorobenzamido] ethylpiperazine (18F-
MPPF) is a radiotracer used in clinical PET studies for the visualization of serotonin-1A (5 …
MPPF) is a radiotracer used in clinical PET studies for the visualization of serotonin-1A (5 …
Radiosynthesis and preclinical evaluation of 18F-F13714 as a fluorinated 5-HT1A receptor agonist radioligand for PET neuroimaging
PET brain imaging of the serotonin 1A (5-hydroxytryptamine 1A [5-HT1A]) receptor has been
widely used in clinical studies. Currently, only a few well-validated radiolabeled antagonist …
widely used in clinical studies. Currently, only a few well-validated radiolabeled antagonist …
Differential effects of paroxetine on raphe and cortical 5-HT1A binding: a PET study in monkeys
G Giovacchini, L Lang, Y Ma, P Herscovitch… - Neuroimage, 2005 - Elsevier
Positron emission tomography (PET) ligands that are sensitive to transient changes in
serotonin (5-HT) concentration are desirable for studies of neuropsychiatric diseases. Few …
serotonin (5-HT) concentration are desirable for studies of neuropsychiatric diseases. Few …