Abstract Mitochondria contain about 1,000–1,500 proteins that fulfil multiple functions.
Mitochondrial proteins originate from two genomes: mitochondrial and nuclear. Hence …

Significance: Mitochondria play a critical role in the physiology of the heart by controlling
cardiac metabolism, function, and remodeling. Accumulation of fragmented and damaged …

Cells maintain membrane fluidity by regulating lipid saturation, but the molecular
mechanisms of this homeoviscous adaptation remain poorly understood. We have …

Mitochondria undergo continuous challenges in the course of their life, from their generation
to their degradation. These challenges include the management of reactive oxygen species …

Mitochondria undergo frequent fusion and fission events to adapt their morphology to
cellular needs. Homotypic docking and fusion of outer mitochondrial membranes are …

Cdc48/p97 is a ring-shaped, ATP-driven hexameric motor, essential for cellular viability. It
specifically unfolds and extracts ubiquitylated proteins from membranes or protein …

From mitochondrial quality control pathways to the regulation of specific functions, the
Ubiquitin Proteasome System (UPS) could be compared to a Swiss knife without which …

Cdc48/p97, a ubiquitin-selective chaperone, orchestrates the function of E3 ligases and
deubiquitylases (DUBs). Here, we identify a new function of Cdc48 in ubiquitin-dependent …

Mitofusins are large transmembrane GTPases of the dynamin-related protein family, and are
required for the tethering and fusion of mitochondrial outer membranes. Their full-length …

Mitofusins are large GTPases that trigger fusion of mitochondrial outer membranes. Similarly
to the human mitofusin Mfn2, which also tethers mitochondria to the endoplasmic reticulum …