DAF-16, the only forkhead box transcription factors class O (FoxO) homolog in
Caenorhabditis elegans, integrates signals from upstream pathways to elicit transcriptional …

Caenorhabditis elegans survives on ephemeral food sources in the wild, and the species
has a variety of adaptive responses to starvation. These features of its life history make the …

While aging was traditionally viewed as a stochastic process of damage accumulation, it is
now clear that aging is strongly influenced by genetics. The identification and …

Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many
organisms, ranging from simple invertebrates to mammals, including humans. Many seminal …

Host genetic landscapes can shape microbiome assembly in the animal gut by contributing
to the establishment of distinct physiological environments. However, the genetic …

Nutrients are necessary for life, as they are a crucial requirement for biological processes
including reproduction, somatic growth, and tissue maintenance. Therefore, signaling …

Taking advantage of Drosophila as a genetically tractable experimental animal much
progress has been made in our understanding of how the insulin/IGF signaling (IIS) pathway …

Glucose homeostasis and growth essentially depend on the hormone insulin engaging its
receptor. Despite biochemical and structural advances, a fundamental contradiction has …

The human genome encodes 10 insulin-like genes, whereas the Caenorhabditis elegans
genome remarkably encodes 40 insulin-like genes. Knockout strategies to determine the …

Neural information processing entails a high energetic cost, but its maintenance is crucial for
animal survival. However, the brain's energy conservation strategies are incompletely …