[HTML][HTML] Human lung epithelial cell cultures for analysis of inhaled toxicants: Lessons learned and future directions

PS Hiemstra, G Grootaers, AM van der Does, CAM Krul… - Toxicology in vitro, 2018 - Elsevier
The epithelium that covers the conducting airways and alveoli is a primary target for inhaled
toxic substances, and therefore a focus in inhalation toxicology. The increasing concern …

[HTML][HTML] Harnessing organs-on-a-chip to model tissue regeneration

DN Tavakol, S Fleischer, G Vunjak-Novakovic - Cell Stem Cell, 2021 - cell.com
Tissue engineering has markedly matured since its early beginnings in the 1980s. In
addition to the original goal to regenerate damaged organs, the field has started to explore …

A digital light processing 3D printed magnetic bioreactor system using silk magnetic bioink

O Ajiteru, KY Choi, TH Lim, H Hong, YJ Lee… - …, 2021 - iopscience.iop.org
Among various bioreactors used in the field of tissue engineering and regenerative
medicine, a magnetic bioreactor is more capable of providing steady force to the cells while …

Lung toxicity of particulates and gaseous pollutants using ex-vivo airway epithelial cell culture systems

R Lakhdar, S Mumby, H Abubakar-Waziri, A Porter… - Environmental …, 2022 - Elsevier
Air pollution consists of a multi-faceted mix of gases and ambient particulate matter (PM)
with diverse organic and non-organic chemical components that contribute to increasing …

How to build a lung: latest advances and emerging themes in lung bioengineering

MM De Santis, DA Bölükbas… - European …, 2018 - Eur Respiratory Soc
Chronic respiratory diseases remain a major cause of morbidity and mortality worldwide.
The only option at end-stage disease is lung transplantation, but there are not enough donor …

[HTML][HTML] The interplay of cells, polymers, and vascularization in three-dimensional lung models and their applications in COVID-19 research and therapy

TA Ahmed, B Eldaly, S Eldosuky, H Elkhenany… - Stem Cell Research & …, 2023 - Springer
Millions of people have been affected ever since the emergence of the corona virus disease
of 2019 (COVID-19) outbreak, leading to an urgent need for antiviral drug and vaccine …

Advances in bioreactors for lung bioengineering: From scalable cell culture to tissue growth monitoring

SH Mahfouzi, G Amoabediny… - Biotechnology and …, 2021 - Wiley Online Library
Lung bioengineering has emerged to resolve the current lung transplantation limitations and
risks, including the shortage of donor organs and the high rejection rate of transplanted …

Development and validation of an open-source, disposable, 3D-printed in vitro environmental exposure system for Transwell culture inserts

A Chandiramohan, M Dabaghi, JA Aguiar… - ERJ Open …, 2021 - Eur Respiratory Soc
Accessible in vitro models recapitulating the human airway that are amenable to study
whole cannabis smoke exposure are needed for immunological and toxicological studies …

Harnessing Tissue Engineering Approaches to Develop Advanced 3D Models for Respiratory Drug Development and Respiratory Regenerative Therapies

L Soriano - 2022 - repository.rcsi.com
Respiratory diseases and major airway trauma represent a global healthcare emergency
with most treatment options providing symptomatic relief rather than curative treatment. In …

Decellularized human-sized pulmonary scaffolds for lung tissue engineering: a comprehensive review

SH Mahfouzi, SH Safiabadi Tali… - Regenerative …, 2021 - Taylor & Francis
The ultimate goal of lung bioengineering is to produce transplantable lungs for human
beings. Therefore, large-scale studies are of high importance. In this paper, we review the …