[HTML][HTML] Histone tail conformations: a fuzzy affair with DNA
M Ghoneim, HA Fuchs, CA Musselman - Trends in biochemical sciences, 2021 - cell.com
The core histone tails are critical in chromatin structure and signaling. Studies over the past
several decades have provided a wealth of information on the histone tails and their …
several decades have provided a wealth of information on the histone tails and their …
The physics of epigenetics
In higher organisms, all cells share the same genome, but every cell expresses only a
limited and specific set of genes that defines the cell type. During cell division, not only the …
limited and specific set of genes that defines the cell type. During cell division, not only the …
[HTML][HTML] Histone acetylation regulates chromatin accessibility: role of H4K16 in inter-nucleosome interaction
R Zhang, J Erler, J Langowski - Biophysical journal, 2017 - cell.com
The N-terminal tail of histone H4 is an indispensable mediator for inter-nucleosome
interaction, which is required for chromatin fiber condensation. H4K16 acetylation …
interaction, which is required for chromatin fiber condensation. H4K16 acetylation …
Development and classes of epigenetic drugs for cancer
D Dhanak, P Jackson - Biochemical and biophysical research …, 2014 - Elsevier
Emerging evidence supports an important, etiologic role for epigenetic modifications in
cancer. Various post translational modifications of histone proteins together with DNA …
cancer. Various post translational modifications of histone proteins together with DNA …
Revealing transient structures of nucleosomes as DNA unwinds
The modulation of DNA accessibility by nucleosomes is a fundamental mechanism of gene
regulation in eukaryotes. The nucleosome core particle (NCP) consists of 147 bp of DNA …
regulation in eukaryotes. The nucleosome core particle (NCP) consists of 147 bp of DNA …
[HTML][HTML] Linker histone defines structure and self-association behaviour of the 177 bp human chromatosome
Linker histones play essential roles in the regulation and maintenance of the dynamic
chromatin structure of higher eukaryotes. The influence of human histone H1. 0 on the …
chromatin structure of higher eukaryotes. The influence of human histone H1. 0 on the …
[HTML][HTML] Solution scattering and FRET studies on nucleosomes reveal DNA unwrapping effects of H3 and H4 tail removal
Using a combination of small-angle X-ray scattering (SAXS) and fluorescence resonance
energy transfer (FRET) measurements we have determined the role of the H3 and H4 …
energy transfer (FRET) measurements we have determined the role of the H3 and H4 …
Atomistic simulation of stacked nucleosome core particles: tail bridging, the H4 tail, and effect of hydrophobic forces
S Saurabh, MA Glaser, Y Lansac… - The Journal of Physical …, 2016 - ACS Publications
We report the first atomistic simulation of two stacked nucleosome core particles (NCPs),
with an aim to understand, in molecular detail, how they interact, the effect of salt …
with an aim to understand, in molecular detail, how they interact, the effect of salt …
[HTML][HTML] The influence of ionic environment and histone tails on columnar order of nucleosome core particles
NV Berezhnoy, Y Liu, A Allahverdi, R Yang, CJ Su… - Biophysical journal, 2016 - cell.com
The nucleosome core particle (NCP) is the basic building block of chromatin. Nucleosome-
nucleosome interactions are instrumental in chromatin compaction, and understanding NCP …
nucleosome interactions are instrumental in chromatin compaction, and understanding NCP …
The conformational state of the nucleosome entry–exit site modulates TATA box-specific TBP binding
AR Hieb, A Gansen, V Böhm… - Nucleic acids …, 2014 - academic.oup.com
The TATA binding protein (TBP) is a critical transcription factor used for nucleating assembly
of the RNA polymerase II machinery. TBP binds TATA box elements with high affinity and …
of the RNA polymerase II machinery. TBP binds TATA box elements with high affinity and …