[HTML][HTML] Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical potential

L Gao, Y Zhang, K Sterling, W Song - Translational neurodegeneration, 2022 - Springer
Synaptic abnormalities are a cardinal feature of Alzheimer's disease (AD) that are known to
arise as the disease progresses. A growing body of evidence suggests that pathological …

[HTML][HTML] Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice

Q Li, H Chan, WX Liu, CA Liu, Y Zhou, D Huang… - Cancer Cell, 2023 - cell.com
Carnobacterium maltaromaticum was found to be specifically depleted in female patients
with colorectal cancer (CRC). Administration of C. maltaromaticum reduces intestinal tumor …

VPS10P domain receptors: sorting out brain health and disease

AR Malik, TE Willnow - Trends in Neurosciences, 2020 - cell.com
VPS10P (vacuolar protein sorting 10 protein) domain receptors are neuronal sorting
receptors that direct cargo proteins to their destined location in subcellular compartments of …

The role of central neurotensin in regulating feeding and body weight

J Ramirez-Virella, GM Leinninger - Endocrinology, 2021 - academic.oup.com
The small peptide neurotensin (Nts) is implicated in myriad processes including analgesia,
thermoregulation, reward, arousal, blood pressure, and modulation of feeding and body …

Spinal neuron-glia-immune interaction in cross-organ sensitization

LY Qiao, N Tiwari - American Journal of Physiology …, 2020 - journals.physiology.org
Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), historically
considered as regional gastrointestinal disorders with heightened colonic sensitivity, are …

[HTML][HTML] Intrathecal liproxstatin-1 delivery inhibits ferroptosis and attenuates mechanical and thermal hypersensitivities in rats with complete Freund's adjuvant-induced …

YF Deng, P Xiang, JY Du, JF Liang… - Neural regeneration …, 2023 - journals.lww.com
Previous studies have confirmed the relationship between iron-dependent ferroptosis and a
peripheral nerve injury-induced neuropathic pain model. However, the role of ferroptosis in …

[HTML][HTML] Management of postoperative pain after elective craniotomy: a prospective randomized controlled trial of a neurosurgical Enhanced Recovery after Surgery …

L Qu, B Liu, H Zhang, EW Sankey, W Chai… - … Journal of Medical …, 2020 - ncbi.nlm.nih.gov
Objective: To prospectively evaluate the efficacy of a neurosurgical enhanced recovery after
surgery (ERAS) protocol on the management of postoperative pain after elective …

Therapeutic approaches targeting the neurotensin receptors

MR Iyer, G Kunos - Expert Opinion on Therapeutic Patents, 2021 - Taylor & Francis
Introduction: Neurotensin is a gut-brain peptide hormone, a 13 amino acid neuropeptide
found in the central nervous system and in the GI tract. The neurotensinergic system is …

proBDNF/p75NTR promotes rheumatoid arthritis and inflammatory response by activating proinflammatory cytokines

CR Yang, HJ Ding, M Yu, FH Zhou, CY Han… - The FASEB …, 2022 - Wiley Online Library
P75 pan‐neurotrophin receptor (p75NTR) is an important receptor for the role of
neurotrophins in survival and death of neurons during development and after nerve injury …

[HTML][HTML] A pain killer without analgesic tolerance designed by co-targeting PSD-95-nNOS interaction and α2-containning GABAARs

J Li, L Zhang, C Xu, YY Shen, YH Lin, Y Zhang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Overactivation of N-methyl-D-aspartate receptor (NMDAR) in the spinal cord dorsal horn
(SDH) in the setting of injury represents a key mechanism of neuropathic pain. However …