Improved personalized adjustment of primary therapy to the perceived risk of relapse by
using new prognostic markers for treatment stratification may be beneficial to patients with …

Based on new data and increased understanding of disease molecular genetics, the
international consensus classification (ICC) has made several changes in the diagnosis and …

B‑cell acute lymphoblastic lymphoma (B‑ALL) is a disease found mainly in children and in
young adults. B‑ALL is characterized by the rapid proliferation of poorly differentiated …

This review addresses changes and updates in eosinophilic disorders under the
International Consensus Classification (ICC). The previous category of myeloid/lymphoid …

Abstract Dana-Farber Cancer Institute (DFCI) ALL Consortium Protocol 05-001 tested a new
risk stratification system in children and adolescents with newly diagnosed acute …

Background ABL-class fusion genes other than BCR–ABL1 have been identified in
approximately 3% of children with newly diagnosed acute lymphocytic leukaemia, and …

Background/objectives While outcomes for pediatric T‐cell acute lymphoblastic leukemia (T‐
ALL) are favorable, there are few widely accepted prognostic factors, limiting the ability to …

Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a common
subtype of B-lineage acute lymphoblastic leukemia (B-ALL) with increasing frequency …

IKAROS is a transcription factor forming homo-and heterodimers and regulating lymphocyte
development and function. Germline mutations affecting the IKAROS N-terminal DNA …

BCR/ABL1–like acute lymphoblastic leukemia (ALL) accounts for 15% to 30% of B‐lineage
ALL, with a peak of incidence occurring in adolescence. This subgroup of patients is …