Background Physical exercise training may form an important part of regular care for people
with cystic fibrosis. This is an update of a previously published review. Objectives To assess …

The host inflammatory response in cystic fibrosis (CF) lung disease has long been
recognized as a central pathological feature and an important therapeutic target. Indeed …

Physiotherapy management is a key element of care for people with cystic fibrosis (CF)
throughout the lifespan. Although considerable evidence exists to support physiotherapy …

Mammalian airways normally regulate the volume of a thin liquid layer, the periciliary liquid
(PCL), to facilitate the mucus clearance component of lung defense. Studies under standard …

▪ Abstract The physical removal of viruses and bacteria on the mucociliary escalator is an
important aspect of the mammalian lung's innate defense mechanism. The volume of airway …

Effective clearance of mucus is a critical innate airway defense mechanism, and under
appropriate conditions, can be stimulated to enhance clearance of inhaled pathogens. It has …

Background Long-term exercise interventions have been shown to improve vital capacity in
cystic fibrosis (CF). Yet, no data are available indicating positive effects of long-term exercise …

Background The physiologic mechanisms by which exercise may clear secretions in
subjects with cystic fibrosis (CF) are unknown. The purpose of this study was to compare …

Cystic fibrosis is a genetic disease caused by mutations in the cystic fibrosis transmembrane
conductance regulator (CFTR) gene, leading to dysfunction of the CFTR protein. CFTR …

This is the second in a series of four papers updating the European Cystic Fibrosis Society
(ECFS) standards for the care of people with CF. This paper focuses on establishing and …